ArticleThe American journal of pathology2006
Liver-type fatty acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 83 citations in OpenAlex.
- Renoprotective effects of human L-type fatty acid-binding protein (hL-FABP) in rhabdomyolysis-induced acute kidney injury.Scientific reports · 2025Article
- Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Lipidomic study of kidney in a mouse model with urine flow obstruction.Scientific reports · 2024Article
- Protein Biomarkers in Chronic Kidney Disease in Children-What Do We Know So Far?Journal of clinical medicine · 2023Review
- Urinary L-type fatty acid-binding protein is a predictor of cisplatin-induced acute kidney injury.BMC nephrology · 2022Article
- Extracellular Vesicles in Redox Signaling and Metabolic Regulation in Chronic Kidney Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.The Journal of pathology · 2021Article
- Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Renal expression and urinary excretion of liver-type fatty acid-binding protein in cats with renal disease.Journal of veterinary internal medicine · 2020Article
- Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice.International journal of biological sciences · 2020Article
- FABP1 and FABP2 as markers of diabetic nephropathy.International journal of medical sciences · 2020Observational
- Temporal changes in urinary excretion of liver-type fatty acid binding protein (L-FABP) in acute kidney injury model of domestic cats: a preliminary study.The Journal of veterinary medical science · 2019Article
- Early detection of unilateral ureteral obstruction by desorption electrospray ionization mass spectrometry.Scientific reports · 2019Article
- Measurement of urinary biomarkers in a case of tubulointerstitial nephritis and uveitis syndrome during glucocorticoid treatment.CEN case reports · 2018Article
- Early postoperative measurement of fibroblast growth factor 23 predicts severe acute kidney injury in infants after cardiac surgery .Clinical nephrology · 2018Article
- Urinary biomarkers of cell cycle arrest are delayed predictors of acute kidney injury after pediatric cardiopulmonary bypass.Pediatric nephrology (Berlin, Germany) · 2017Article
- Urinary l-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy.Renal failure · 2017Article
- Urinary L-FABP as a marker of vesicoureteral reflux in children: could it also have a protective effect on the kidney?International urology and nephrology · 2017Article
- Early detection of acute kidney injury after pediatric cardiac surgery.Progress in pediatric cardiology · 2016Article
- Recent insights into the biological functions of liver fatty acid binding protein 1.Journal of lipid research · 2015Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver-type fatty-acid-binding protein (L-FABP), which has high affinity for long-chain fatty acid oxidation products, may be an effective endogenous antioxidant. To examine the role of L-FABP in tubulointerstitial damage, we used a unilateral ureteral obstruction (UUO) model. We established human L-FABP (hL-FABP) gene transgenic (Tg) mice and compared the tubulointerstitial pathology of the Tg mice (n = 23) with that of the wild-type (WT) mice (n = 23). Mice were sacrificed on days 2, 4, 5, or 7 after UUO. Although mouse L-FABP was not expressed in WT mice, hL-FABP was expressed in the proximal tubules of the Tg mice with UUO (UUO-Tg) and in sham-operated Tg mice. The expression of renal hL-FABP was significantly increased in UUO-Tg compared with sham-operated Tg mice. The number of macrophages (F4/80) infiltrating the interstitium and the level of expression of MCP-1 and MCP-3 were significantly lower in UUO-Tg kidneys compared with UUO-WT kidneys. In UUO-Tg kidneys, the degree of the tubulointerstitial injury and the deposition of type I collagen were significantly lower than that of UUO-WT kidneys. On day 7, lipid peroxidation product accumulated in the UUO-WT kidneys but not in that of UUO-Tg kidneys. In conclusion, renal L-FABP may reduce the oxidative stress in the UUO model, ameliorating tubulointerstitial damage.
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