ReviewArchives of disease in childhood2007
What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock?
Review in Archives of disease in childhood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00732277 (Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis (Steroids in Paediatric Sepsis, StePS) - a Randomised Pilot Study
Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- Change in vasoactive inotropic score following hydrocortisone administration in the pediatric intensive care unit: a PICU data collaborative study, 2010-2022.Frontiers in pediatrics · 2026Article
- Using newborn screening analytes to identify cases of neonatal sepsis.Scientific reports · 2017Article
- Relative Adrenal Insufficiency in Pediatric Septic Shock.Journal of pediatric intensive care · 2015Review
- Effect of high dose of steroid on plateletcount in acute stage of dengue Fever with thrombocytopenia.Journal of clinical and diagnostic research : JCDR · 2013Article
- Advances in monitoring and management of shock.Pediatric clinics of North America · 2013Review
- Effects of low-dose hydrocortisone therapy on immune function in neonatal horses.Pediatric research · 2011Article
- Adrenocortical insufficiency in horses and foals.The Veterinary clinics of North America. Equine practice · 2011Review
- Collaborative pediatric critical care research network: looking back and moving forward.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2010Article
- Steroids in septic shock: the confusion continues.Archives of disease in childhood · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies show that children who die from fulminant meningococcaemia have very low cortisol:adrenocorticotrophic hormone (ACTH) ratios within the first 8 h of presentation to emergency facilities compared with survivors. This observation supports the possibility that adrenal insufficiency may contribute to rapid cardiovascular collapse in these children. In recent years, the use of hydrocortisone treatment has become increasingly popular in the care of adult and paediatric patients with septic shock. In this review, the classical adrenal insufficiency literature is presented and the existing rationale for using titrated hydrocortisone treatment (2-50 mg/kg/day) to reverse catecholamine-resistant shock in children who have absolute adrenal insufficiency (defined by peak cortisol level <18 microg/dl after ACTH challenge) or pituitary, hypothalamic or adrenal axis insufficiency is provided. In addition, the concept of relative adrenal insufficiency (basal cortisol >18 microg/dl but a peak response to ACTH <9 microg/dl) is reviewed. Although there is a good rationale supporting the use of 7 days of low-dose hydrocortisone treatment (about 5 mg/kg/day) in adults with this condition and catecholamine resistant septic shock, the paediatric literature suggests that it is prudent to conduct more studies before recommending this approach in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.