ArticleMolecular and cellular biology1990
Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
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- Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression.Carcinogenesis · 2013Article
- A doxycycline-inducible, tissue-specific aromatase-expressing transgenic mouse.Transgenic research · 2012Article
- Specific in vivo expression in type II pneumocytes of the Jaagsiekte sheep retrovirus long terminal repeat in transgenic mice.Virology · 2008Article
- Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages.Molecular oncology · 2007Article
- Differentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression.Molecular and cellular biology · 2006Article
- Conversion of mouse mammary tumor virus to a lymphomagenic virus.Journal of virology · 2005Article
- The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis.Journal of virology · 2003Article
- What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas.Leukemia · 2002Review
- CDP binding to multiple sites in the mouse mammary tumor virus long terminal repeat suppresses basal and glucocorticoid-induced transcription.Journal of virology · 2002Article
- Structure and dynamic properties of a glucocorticoid receptor-induced chromatin transition.Molecular and cellular biology · 2000Article
- CDP is a repressor of mouse mammary tumor virus expression in the mammary gland.Journal of virology · 2000Article
- Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice.Oncogene · 1999Article
- Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation.Molecular and cellular biology · 1999Article
- Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.Journal of virology · 1999Article
- Mouse mammary tumor virus sequences responsible for activating cellular oncogenes.Journal of virology · 1998Article
- Matrix metalloproteinases in remodeling of the normal and neoplastic mammary gland.Journal of mammary gland biology and neoplasia · 1998Review
- Construction and characterization of a hybrid mouse mammary tumor virus/murine leukemia virus-based retroviral vector.Journal of virology · 1998Article
- Overexpression of the matrix metalloproteinase matrilysin results in premature mammary gland differentiation and male infertility.Molecular biology of the cell · 1998Article
- RNA polymerase II transcription complex assembly in nuclear extracts.Gene expression · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mouse mammary tumor virus (MMTV) is an endogenous murine retrovirus that is expressed in the epithelial cells of the mammary and salivary glands, lungs, kidneys, and seminal vesicles and in the lymphoid cells of the spleen and thymus. Several studies have shown that the long terminal repeat (LTR) of this virus can direct the expression of reporter genes to the same tissues in transgenic mice. To determine whether multiple regulatory elements within the LTR are involved in this tissue-specific expression, we have established lines of transgenic mice containing transgenes that have deletions in the MMTV LTR. Deletions of all LTR sequences upstream of -364 or of LTR sequences from -165 to -665 both result in the expression of linked reporter genes such as the simian virus 40 early region or the bacterial enzyme chloramphenicol acetyltransferase in novel sites, such as the heart, brain, and skeletal muscle; expression of endogenous MMTV and transgenes containing the full-length LTR is not detected in these organs. Negative regulation appears to involve more than one region, since deletion of sequences between either -201 and -471 or -201 and -344, as well as sequences upstream of -364, results in inappropriate expression in heart, brain, and skeletal muscle. Therefore, a negative regulatory element(s) in the MMTV LTR can suppress transcription from the viral promoter in several different organs. This represents the first example of generalized negative regulatory elements that act in many different tissues in transgenic mice to prevent inappropriate expression of a gene.
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