ArticleMolecular and cellular biology2006
Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 96 citations in OpenAlex.
- Article
- The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.Nucleic acids research · 2026Article
- The Over-Irradiation Metabolite Derivative, 24-Hydroxylumister-olMetabolites · 2023Article
- XPG in the Nucleotide Excision Repair and Beyond: a study on the different functional aspects of XPG and its associated diseases.Molecular biology reports · 2022Review
- Article
- Active DNA damage eviction by HLTF stimulates nucleotide excision repair.Molecular cell · 2022Article
- XPG: a multitasking genome caretaker.Cellular and molecular life sciences : CMLS · 2022Review
- Article
- Ribosomal protein S3 associates with the TFIIH complex and positively regulates nucleotide excision repair.Cellular and molecular life sciences : CMLS · 2021Article
- Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.DNA repair · 2020Review
- Exploring new potential role of DDB2 by host cell reactivation assay in human tumorigenic cells.BMC cancer · 2019Article
- Article
- SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.Nature communications · 2015Article
- Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.Cell reports · 2015Article
- Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair.Cell cycle (Georgetown, Tex.) · 2015Article
- Generation of cell-based systems to visualize chromosome damage and translocations in living cells.Nature protocols · 2014Article
- Understanding nucleotide excision repair and its roles in cancer and ageing.Nature reviews. Molecular cell biology · 2014Review
- Yeast RAD2, a homolog of human XPG, plays a key role in the regulation of the cell cycle and actin dynamics.Biology open · 2014Article
- Molecular mechanism of global genome nucleotide excision repair.Acta naturae · 2014Article
- Robustness of DNA repair through collective rate control.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structure-specific endonuclease XPG is an indispensable core protein of the nucleotide excision repair (NER) machinery. XPG cleaves the DNA strand at the 3' side of the DNA damage. XPG binding stabilizes the NER preincision complex and is essential for the 5' incision by the ERCC1/XPF endonuclease. We have studied the dynamic role of XPG in its different cellular functions in living cells. We have created mammalian cell lines that lack functional endogenous XPG and stably express enhanced green fluorescent protein (eGFP)-tagged XPG. Life cell imaging shows that in undamaged cells XPG-eGFP is uniformly distributed throughout the cell nucleus, diffuses freely, and is not stably associated with other nuclear proteins. XPG is recruited to UV-damaged DNA with a half-life of 200 s and is bound for 4 min in NER complexes. Recruitment requires functional TFIIH, although some TFIIH mutants allow slow XPG recruitment. Remarkably, binding of XPG to damaged DNA does not require the DDB2 protein, which is thought to enhance damage recognition by NER factor XPC. Together, our data present a comprehensive view of the in vivo behavior of a protein that is involved in a complex chromatin-associated process.
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