Should we inhibit type I interferons in sepsis?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

1. Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.European journal of pharmacology · 2020
   Article
2. IFN-β Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome-related Mortality.American journal of respiratory cell and molecular biology · 2018
   Article
3. Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018
   Article
4. Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia.Frontiers in immunology · 2018
   Article
5. Rotavirus Degrades Multiple Interferon (IFN) Type Receptors To Inhibit IFN Signaling and Protects against Mortality from Endotoxin in Suckling Mice.Journal of virology · 2018
   Article
6. Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.Cell reports · 2017
   Article
7. A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling.The Journal of biological chemistry · 2017
   Article
8. Myeloid-derived NF-κB negative regulation of PU.1 and c/EBP-β-driven pro-inflammatory cytokine production restrains LPS-induced shock.Innate immunity · 2017
   Article
9. Murine Cytomegalovirus Disrupts Splenic Dendritic Cell SubsetsFrontiers in immunology · 2017
   Article
10. The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential.Frontiers in immunology · 2017
    Review
11. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β.The Journal of clinical investigation · 2016
    Article
12. Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection-Induced Preterm Birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016
    Article
13. Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
14. Formal modelling of toll like receptor 4 and JAK/STAT signalling pathways: insight into the roles of SOCS-1, interferon-β and proinflammatory cytokines in sepsis.PloS one · 2014
    Article
15. Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
16. The regulation of inflammation by interferons and their STATs.JAK-STAT · 2013
    Review
17. Activation and regulation of interferon-β in immune responses.Immunologic research · 2012
    Review
18. Type I interferon drives tumor necrosis factor-induced lethal shock.The Journal of experimental medicine · 2009
    Article
19. Live, attenuated strains of Listeria and Salmonella as vaccine vectors in cancer treatment.Bioengineered bugs
    Review
20. Gene Expression Profile of Human Cytokines in Response tomSphere
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors at 2 institutions in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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