ArticleFEMS immunology and medical microbiology2006
Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB.
Article in FEMS immunology and medical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Elucidation of independently modulated genes inmSystems · 2023Article
- Necrotizing fasciitis and fatal septic shock associated withAutopsy & case reports · 2023Article
- Current Understanding of Group A Streptococcal Biofilms.Current drug targets · 2019Review
- RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus.Infection and immunity · 2018Article
- Streptococcus pyogenes biofilms-formation, biology, and clinical relevance.Frontiers in cellular and infection microbiology · 2015Review
- Dynamics of speB mRNA transcripts in Streptococcus pyogenes.Journal of bacteriology · 2012Article
- Dispersal of Group A streptococcal biofilms by the cysteine protease SpeB leads to increased disease severity in a murine model.PloS one · 2011Article
- Srv mediated dispersal of streptococcal biofilms through SpeB is observed in CovRS+ strains.PloS one · 2011Article
- Allelic replacement of the streptococcal cysteine protease SpeB in a Δsrv mutant background restores biofilm formation.BMC research notes · 2010Article
- Loss of the group A Streptococcus regulator Srv decreases biofilm formation in vivo in an otitis media model of infection.Infection and immunity · 2010Article
- Streptococcus adherence and colonization.Microbiology and molecular biology reviews : MMBR · 2009Review
- Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB).Microbiology (Reading, England) · 2009Article
- Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function.Microbiology (Reading, England) · 2008Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Group A Streptococcus is characterized by the ability to cause a diverse number of human infections including pharyngitis, necrotizing fasciitis, toxic shock syndrome, and acute rheumatic fever, yet the regulation of streptococcal genes involved in disease processes and survival in the host is not completely understood. Genome scale analysis has revealed a complex regulatory network including 13 two-component regulatory systems and more than 100 additional putative regulators, the majority of which remain uncharacterized. Among these is the streptococcal regulator of virulence, Srv, the first Group A Streptococcus member of the Crp/Fnr family of transcriptional regulators. Previous work demonstrated that the loss of srv resulted in a significant decrease in Group A Streptococcus virulence. To begin to define the gene products influenced by Srv, we combined microarray and two-dimensional gel electrophoresis analysis. Loss of srv results in a chromosome wide reduction of gene transcription and changes in the production of the extracellular virulence factors Sic (streptococcal inhibitor of complement) and SpeB (cysteine proteinase). Sic levels are reduced in the srv mutant, whereas the extracellular concentration and activity of SpeB is increased. These data link Srv to the increasingly complex GAS regulatory network.
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