ReviewFamilial cancer2006
Current ideas in desmoid tumours.
Review in Familial cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05111964 (A Pilot Study in High Intensity Focused Ultrasound Ablation of Soft Tissue Sarcoma and Small Symptomatic Desmoid Tumours), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study in High Intensity Focused Ultrasound Ablation of Soft Tissue Sarcoma and Small Symptomatic Desmoid Tumours
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.
- Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.The British journal of surgery · 2024Guideline
- Twist of fate: Acute small-bowel volvulus caused by a giant mesenteric desmoid-type fibromatosis: A case report and literature review.Radiology case reports · 2026Article
- Updates and controversies for desmoids in familial adenomatous polyposis.Familial cancer · 2025Review
- Reexamining Multisystem Desmoid Tumors Linked to Gardner's Syndrome: A Clinical Case.Case reports in gastrointestinal medicine · 2025Article
- Management of Desmoid Disease in Familial Adenomatous Polyposis.Clinics in colon and rectal surgery · 2024Review
- Recent Advances and Current Management for Desmoid Tumor Associated with Familial Adenomatous Polyposis.Journal of the anus, rectum and colon · 2023Review
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer.International journal of clinical oncology · 2021Article
- The Role of Radiation Therapy for Symptomatic Desmoid Tumors.Current treatment options in oncology · 2021Review
- Practical management of polyposis syndromes.Frontline gastroenterology · 2019Review
- Familial Polyposis Coli: The Management of Desmoid Tumor Bleeding.Open medicine (Warsaw, Poland) · 2019Article
- Urological sequelae of desmoids associated with familial adenomatous polyposis.Familial cancer · 2018Article
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version).Journal of the anus, rectum and colon · 2018Review
- The treatment of desmoid tumors associated with familial adenomatous polyposis: the results of a Japanese multicenter observational study.Surgery today · 2017Article
- Does routine colonoscopy help diagnose familial adenomatous polyposis in patients presenting with desmoid tumors but no gastrointestinal symptoms?International journal of colorectal disease · 2017Article
- The genetic basis of colonic adenomatous polyposis syndromes.Hereditary cancer in clinical practice · 2017Review
- [Surgical aspects of indications and techniques for adenomatous polyposis variants].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Review
- Surgical considerations in FAP-related pouch surgery: Could we do better?Familial cancer · 2016Review
- Familial adenomatous polyposis in pediatrics: natural history, emerging surveillance and management protocols, chemopreventive strategies, and areas of ongoing debate.Familial cancer · 2016Article
- Desmoid Tumors: A Clear Perspective or a Persisting Enigma? A Case Report and Review of Literature.World journal of oncology · 2016Article
- Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours.Oncoscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Desmoid tumours are rare neoplasms of fibroblastic origin which arise with disproportionate frequency in patients with familial adenomatous polyposis (FAP). They are thought to develop in about 10-25% of FAP patients and may be the leading cause of death amongst those who have undergone colectomy. Risk factors include trauma, having a distal germline APC mutation, having a family history of desmoids, and probably oestrogens. In very high-risk individuals there may be a case for delay of colectomy or chemoprophylaxis at the time of surgery. Desmoids are now known to be true neoplasms but with normal telomere length and telomerase activity. FAP-associated tumours seem to carry biallelic APC mutations, one of which lies in the distal part of the gene. Such loss of wild-type APC seems to occur relatively late in tumour development. It is likely that beta-catenin plays an important role in tumourigenesis. FAP-associated desmoids tend to arise in the abdomen or abdominal wall. CT scanning gives the best information on tumour anatomy whilst T2-weighted MRI indicates likely behaviour. Treatment may simply consist of observation. Otherwise, usual first-line therapy is with sulindac with or without an anti-oestrogen. Cytotoxic chemotherapy is an option in unresectable tumours. Surgery is a reasonable first-line treatment in abdominal wall tumours but is risky for intra-abdominal tumours and may necessitate massive small bowel resection. Desmoids are the greatest remaining challenge in the management of FAP and further research into their aetiology needs to be combined with multicentre clinical trials of new treatments in order to improve management of the disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.