ReviewFamilial cancer2006
Familial adenomatous polyposis: The practical applications of clinical and molecular screening.
Review in Familial cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer.International journal of clinical oncology · 2021Article
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version).Journal of the anus, rectum and colon · 2018Review
- Attenuated adenomatous polyposis of the large bowel: Present and future.World journal of gastroenterology · 2017Article
- Preferences for genetic testing for colorectal cancer within a population-based screening program: a discrete choice experiment.European journal of human genetics : EJHG · 2016Article
- Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer.World journal of gastrointestinal oncology · 2016Review
- Molecular biology of gynecological cancer.Oncology letters · 2016Article
- MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.Oncotarget · 2015Article
- The evolution of colorectal cancer genetics-Part 2: clinical implications and applications.Journal of gastrointestinal oncology · 2014Review
- Mainstreaming genetic testing of cancer predisposition genes.Clinical medicine (London, England) · 2014Article
- Review
- Identification of an APC Variant in a Patient with Clinical Attenuated Familial Adenomatous Polyposis.Case reports in medicine · 2014Article
- Identification of patients at risk for hereditary colorectal cancer.Clinics in colon and rectal surgery · 2012Article
- Article
- Lower gastrointestinal tract cancer predisposition syndromes.Hematology/oncology clinics of North America · 2010Review
- Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto Rico.Familial cancer · 2010Article
- The challenge of developmentally appropriate care: predictive genetic testing in young people for familial adenomatous polyposis.Familial cancer · 2010Article
- Uptake of genetic testing and long-term tumor surveillance in von Hippel-Lindau disease.BMC medical genetics · 2010Article
- Familial adenomatous polyposis.Orphanet journal of rare diseases · 2009Review
- The FAP self-concept scale (adult form).Familial cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial adenomatous polyposis (FAP) is an autosomal dominant condition mostly due to a mutation of the APC gene on the chromosome 5q. Carriers have an almost 100% chance of developing colorectal cancer after having multiple (typically 100s to 1000s) of adenomatous polyps. It is usually readily identified through this phenotype of multiple adenomas. Correlations between the location of the family-specific mutation on the APC gene and clinical manifestations of the disease are of some assistance in clinical management, though there is heterogeneity in clinical course even between family members with the same mutation. FAP is important to recognize, as there are disease-specific management implications with respect to offering mutational analysis of the APC (and perhaps other) genes for predictive testing of other family members, endoscopic diagnostic procedures, surveillance planning, and surgical management. Extra-colonic manifestations, including duodenal polyposis, desmoid disease and other tumours, can dominate clinical care after colectomy. The inheritable and lethal nature of the disease, together with the availability of effective treatment strategies, makes a sensitive clinical and psychosocial approach important to maximize compliance and good outcomes for all members of affected families.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.