Evidence map›Paper›PMID 16998642›Full record

ArticleJournal of computational neuroscience2007

Mechanisms of seizure propagation in a cortical model.

Mark A Kramer, Andrew J Szeri, James W Sleigh, Heidi E Kirsch

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of computational neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Suppression of epileptic seizures via Anderson localization.Journal of the Royal Society, Interface · 2017
    Article
  9. Article
  10. Article
  11. Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mark A KramerApplied Science and Technology Graduate Group, University of California, Berkeley, CA 94720-1740, USA.
Andrew J Szeri
James W Sleigh
Heidi E Kirsch

Funding

The Effect of Epilepsy Surgery on Social CognitionK23NS047100 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIRSCH, HEIDI ELYSE · 2004 to 2008
$727k
NINDS NIH HHS K23 NS 047100
6 · The paper itself

Abstract

We consider a mathematical model of mesoscopic human cortical ictal electrical activity. We compare the model results with ictal electrocortical data recorded from three human subjects and show how the two agree. We determine that, in the model system, seizures result from increased connectivity between excitatory and inhibitory cell populations, or from decreased connectivity within either excitatory or inhibitory cell populations. We compare the model results with the disinhibition and 4-AP models of epilepsy and suggest how the model may guide the development of new anticonvulsant therapies.

Indexed as

4-AminopyridineAdultAnticonvulsantsBenzodiazepinesCerebral CortexElectroencephalographyElectrophysiologyFemaleFrontal LobeHumansModels, NeurologicalModels, StatisticalPotassium Channel BlockersSeizuresTemporal Lobe4-AminopyridineAnticonvulsantsBenzodiazepinesPotassium Channel Blockers

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.