Evidence map›Paper›PMID 16998613›Full record

ReviewOdontology2006

Periodontal disease and systemic conditions: a bidirectional relationship.

Jemin Kim, Salomon Amar

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Odontology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06041178 (Efficiency of Flurbiprofen 2.5% in Comparison to 98% Aloe Vera Gel as an Adjunctive Therapy to Scaling and Root Planning in the Initial Treatment of Stage III Chronic Periodontitis in Smoking Patients), which is not on this map. Cited by 249 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 8 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06041178 phase4completednot on this mapstarted 2022, after this paper: background citation

Efficiency of Flurbiprofen 2.5% in Comparison to 98% Aloe Vera Gel as an Adjunctive Therapy to Scaling and Root Planning in the Initial Treatment of Stage III Chronic Periodontitis in Smoking Patients

TypeinterventionalSponsorBeirut Arab UniversityRan2022 to 2023Enrolled60ConditionsPeriodontitis Chronic Generalized SevereArms2.5% flurbiprofen, 98% aloe vera, Placebo
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 8 syntheses or guidelines pooled it, 609 citations in OpenAlex.

  1. Pooled it
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  9. Trial
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  13. Curriculum Gaps in Periodontal Knowledge Among Medical Students: A Cross-Sectional Study.European journal of dental education : official journal of the Association for Dental Education in Europe · 2026
    Article
  14. Article
  15. MPRO3 Regulates Macrophage Polarization and OsteoclastogenesisJournal of microbiology and biotechnology · 2026
    Article
  16. Review
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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jemin KimBoston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston, MA, USA.
Salomon Amar
Boston Medical Center · US

Funding

Inflammation and Infection in AtherosclerosisR01HL076801 · NHLBI · NEW YORK MEDICAL COLLEGE · PI AMAR, SALOMON · 2005 to 2018
$5.3M
NHLBI NIH HHS R01 HL076801
6 · The paper itself

Abstract

For decades, physicians and dentists have paid close attention to their own respective fields, specializing in medicine pertaining to the body and the oral cavity, respectively. However, recent findings have strongly suggested that oral health may be indicative of systemic health. Currently, this gap between allopathic medicine and dental medicine is quickly closing, due to significant findings supporting the association between periodontal disease and systemic conditions such as cardiovascular disease, type 2 diabetes mellitus, adverse pregnancy outcomes, and osteoporosis. Significant effort has brought numerous advances in revealing the etiological and pathological links between this chronic inflammatory dental disease and these other conditions. Therefore, there is reason to hope that the strong evidence from these studies may guide researchers towards greatly improved treatment of periodontal infection that would also ameliorate these systemic illnesses. Hence, researchers must continue not only to uncover more information about the correlations between periodontal and systemic diseases but also to focus on positive associations that may result from treating periodontal disease as a means of ameliorating systemic diseases.

Indexed as

Cardiovascular DiseasesC-Reactive ProteinDiabetes ComplicationsFemaleHumansInfant, Low Birth WeightInfant, NewbornInflammation MediatorsNitric OxideOsteoporosisPeriodontal DiseasesPregnancyPremature BirthC-Reactive ProteinInflammation MediatorsNitric Oxide

Identifiers

PMID16998613
PMCPMC2443711
OpenAlexW2032340782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.