ArticlePathology oncology research : POR2006
Human papilloma virus and p53 expression in bladder cancer in Egypt: relationship to schistosomiasis and clinicopathologic factors.
Article in Pathology oncology research : POR, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The association between human papillomavirus and bladder cancer: Evidence from meta-analysis and two-sample mendelian randomization.Journal of medical virology · 2023Pooled it
- Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features.Asian journal of urology · 2024Review
- A case of condyloma acuminatum of the bladder concurrently diagnosed with urothelial carcinoma.IJU case reports · 2024Article
- Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Development of Urinary Bladder Pre-Neoplasia byThe Korean journal of parasitology · 2017Article
- Schistosoma haematobium egg-induced bladder urothelial abnormalities dependent on p53 are modulated by host sex.Experimental parasitology · 2015Article
- Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer.Trends in parasitology · 2014Review
- Detection of human papillomavirus infection and p16 immunohistochemistry expression in bladder cancer with squamous differentiation.PloS one · 2014Article
- Role of human papillomavirus in the development of urothelial carcinoma.Medical oncology (Northwood, London, England) · 2011Article
- Vaccination against human papilloma virus (HPV): epidemiological evidence of HPV in non-genital cancers.Pathology oncology research : POR · 2011Review
- Incidence analyses of bladder cancer in the Nile delta region of Egypt.Cancer epidemiology · 2009Article
- Tumor markers of bladder cancer: the schistosomal bladder tumors versus non-schistosomal bladder tumors.Journal of experimental & clinical cancer research : CR · 2009Article
- Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer.BMC cancer · 2009Article
- Role of human papillomavirus types 16, 18, and 52 in recurrent cystitis and urinary bladder cancer among Egyptian patients.Medscape journal of medicine · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the current study was to compare the role of p53 and human papillomavirus (HPV) in schistosomiasis-related and schistosomiasis-unrelated carcinoma of the urinary bladder. To achieve this aim, we investigated 114 bladder carcinomas for p53 oncoprotein expression by immunohistochemistry and for human papillomavirus by in situ hybridization technique. The results revealed that 64 tumors (56.1%) were schistosomiasis-associated. Sixty seven (58.8%) were transitional cell carcinomas and 32 (28%) were squamous cell carcinomas. The remaining 15 tumors (13.2%) included adenocarcinomas and sarcomatoid carcinomas. In both schistosomiasis-associated and non-associated carcinomas, p53 oncoprotein expression was significantly higher in poorly differentiated tumors. However, it was significantly higher in locally more invasive tumors in the schistosomal carcinomas only. HPV types 16/18 could be detected in 1 of the 114 bladder carcinomas (0.95%), which was schistosomiasis-related squamous cell carcinoma in situ. These results suggest that p53 immunohistochemistry can be a prognostic factor in both schistosomal and nonschistosomal bladder cancer. More importantly, HPV does not seem to play a role in the pathogenesis of either type of bladder cancer in our country.
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