ArticleThe Journal of clinical investigation2006
Calcineurin/Nfat signaling is required for perinatal lung maturation and function.
Article in The Journal of clinical investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation.Scientific reports · 2016Trial
- Mechanistic Insights and Therapeutic Potential of Wnt5a Signaling in Alveolar Epithelial Cell Development and Bronchopulmonary Dysplasia.Stem cell reviews and reports · 2025Review
- Why some and not others? Understanding vascular phenotypes in genetic developmental lung diseases.Current opinion in pediatrics · 2025Review
- Article
- Sex-Specific Alterations of the Lung Transcriptome at Birth in Mouse Offspring Prenatally Exposed to Vanilla-Flavored E-Cigarette Aerosols and Enhanced Susceptibility to Asthma.International journal of environmental research and public health · 2023Article
- In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice.Toxicological research · 2022Article
- First Steps toward Personalized Therapies for ABCA3 Deficiency.American journal of respiratory cell and molecular biology · 2022Article
- Lung disease manifestations in Down syndrome.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- Comparison Between Sodium Acetate and Sodium Chloride in Parenteral Nutrition for Very Preterm Infants on the Acid-Base Status and Neonatal Outcomes.Pediatric gastroenterology, hepatology & nutrition · 2020Article
- Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.JCI insight · 2018Article
- Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.The Journal of clinical investigation · 2016Article
- BMP signaling is essential in neonatal surfactant production during respiratory adaptation.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Behavioral heterogeneity of adult mouse lung epithelial progenitor cells.Stem cells and development · 2014Article
- Article
- Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.The Journal of biological chemistry · 2012Article
- Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development.PloS one · 2011Article
- Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice.Molecular and cellular biology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Pulmonary surfactant proteins and lipids are required for lung function after birth. Lung immaturity and resultant surfactant deficiency cause respiratory distress syndrome, a common disorder contributing to morbidity and mortality in preterm infants. Surfactant synthesis increases prior to birth in association with formation of the alveoli that mediate efficient gas exchange. To identify mechanisms controlling perinatal lung maturation, the Calcineurin b1 (Cnb1) gene was deleted in the respiratory epithelium of the fetal mouse. Deletion of Cnb1 caused respiratory failure after birth and inhibited the structural maturation of the peripheral lung. Synthesis of surfactant and a lamellar body-associated protein, ABC transporter A3 (ABCA3), was decreased prior to birth. Nuclear factor of activated T cells (Nfat) calcineurin-dependent 3 (Nfatc3), a transcription factor modulated by calcineurin, was identified as a direct activator of Sftpa, Sftpb, Sftpc, Abca3, Foxa1, and Foxa2 genes. The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.