Evidence map›Paper›PMID 16998501›Full record

ReviewOncogene2006

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.

K Gudmundsdottir, A Ashworth

Abstract readReview
PubMed Publisher
In one paragraph

Review in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers.

0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

282 citing papers in PubMed, 615 citations in OpenAlex.

  1. TumorClinical cancer research : an official journal of the American Association for Cancer Research · 2017
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  14. Mammalian Species-Specific Resistance to Mammary Cancer.Journal of mammary gland biology and neoplasia · 2025
    Review
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  18. Article
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222 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

K GudmundsdottirThe Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, UK.
A Ashworth
Breast Cancer Now · GBInstitute of Cancer Research · GB

Funding

Breast Cancer Now BREAST CANCER NOW RESEARCH CENTRE
6 · The paper itself

Abstract

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 appears to involve regulating the function of RAD51 in the repair by homologous recombination. BRCA1 has a broader role upstream of BRCA2, participating in various cellular processes in response to DNA damage. The DNA repair defect associated with mutations in BRCA1 or BRCA2 could be exploited to develop new targeted therapeutic approaches for cancer occurring in mutation carriers.

Indexed as

BRCA1 ProteinBRCA2 ProteinDNA DamageDNA RepairGenomic InstabilityBreast NeoplasmsDNA-Binding ProteinsFemaleGenetic Carrier ScreeningHumansMutationBRCA1 ProteinBRCA2 ProteinDNA-Binding Proteins

Identifiers

PMID16998501
OpenAlexW2062568878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.