ArticleEukaryotic cell2006
The multifunctional beta-oxidation enzyme is required for full symptom development by the biotrophic maize pathogen Ustilago maydis.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Studying Peroxisomes in Ustilago maydis: A Defined Workflow.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Fatty acids in filamentous pathogenic fungi: Multidimensional regulation and pathogenic mechanisms.Virulence · 2025Review
- Article
- An Updated Perspective on the Aromatic Metabolic Pathways of Plant-Derived Homocyclic Aromatic Compounds inMicroorganisms · 2025Review
- A fatty acid elongase complex regulates cell membrane integrity and septin-dependent host infection by the rice blast fungus.Molecular plant pathology · 2024Article
- Identification and molecular detection of the pathogen ofFrontiers in microbiology · 2024Article
- Linking extreme seasonality and gene expression in Arctic marine protists.Scientific reports · 2023Article
- Two Pex5 Proteins With Different Cargo Specificity Are Critical for Peroxisome Function in Ustilago maydis.Frontiers in cell and developmental biology · 2022Article
- Aspergillus niger uses the peroxisomal CoA-dependent β-oxidative genes to degrade the hydroxycinnamic acids caffeic acid, ferulic acid, and p-coumaric acid.Applied microbiology and biotechnology · 2021Article
- The AP-1-like transcription factor ChAP1 balances tolerance and cell death in the response of the maize pathogen Cochliobolus heterostrophus to a plant phenolic.Current genetics · 2020Article
- The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of Ustilago maydis.Molecular plant pathology · 2017Article
- Peroxisome-mitochondria interplay and disease.Journal of inherited metabolic disease · 2015Review
- Peroxisomes and sexual development in fungi.Frontiers in physiology · 2013Review
- Defects in mitochondrial and peroxisomal β-oxidation influence virulence in the maize pathogen Ustilago maydis.Eukaryotic cell · 2012Article
- Peroxisomal and mitochondrial β-oxidation pathways influence the virulence of the pathogenic fungus Cryptococcus neoformans.Eukaryotic cell · 2012Article
- Article
- Pathogen profile update: Fusarium oxysporum.Molecular plant pathology · 2009Review
- Insight into the molecular requirements for pathogenicity of Fusarium oxysporum f. sp. lycopersici through large-scale insertional mutagenesis.Genome biology · 2009Article
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2 authors at 1 institution in 1 country.
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Abstract
The transition from yeast-like to filamentous growth in the biotrophic fungal phytopathogen Ustilago maydis is a crucial event for pathogenesis. Previously, we showed that fatty acids induce filamentation in U. maydis and that the resulting hyphal cells resemble the infectious filaments observed in planta. To explore the potential metabolic role of lipids in the morphological transition and in pathogenic development in host tissue, we deleted the mfe2 gene encoding the multifunctional enzyme that catalyzes the second and third reactions in beta-oxidation of fatty acids in peroxisomes. The growth of the strains defective in mfe2 was attenuated on long-chain fatty acids and abolished on very-long-chain fatty acids. The mfe2 gene was not generally required for the production of filaments during mating in vitro, but loss of the gene blocked extensive proliferation of fungal filaments in planta. Consistent with this observation, mfe2 mutants exhibited significantly reduced virulence in that only 27% of infected seedlings produced tumors compared to 88% tumor production upon infection by wild-type strains. Similarly, a defect in virulence was observed in developing ears upon infection of mature maize plants. Specifically, the absence of the mfe2 gene delayed the development of teliospores within mature tumor tissue. Overall, these results indicate that the ability to utilize host lipids contributes to the pathogenic development of U. maydis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.