ArticleEukaryotic cell2006
Analysis of Euglena gracilis plastid-targeted proteins reveals different classes of transit sequences.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
- Derlin-like proteins are essential for the function of Euglena gracilis chloroplasts.Plant physiology · 2026Article
- Transient molecular chimerism for exploiting xenogeneic organelles.Nature communications · 2026Article
- Structural insights into the divergent evolution of a photosystem I supercomplex inScience advances · 2025Article
- Euglenozoan kleptoplasty illuminates the early evolution of photoendosymbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Glycosylated proteins in the protozoan alga Euglena gracilis: a proteomic approach.FEMS microbiology letters · 2023Article
- The Lipid Composition ofPlant physiology · 2020Article
- Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea.Open biology · 2020Review
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- Peculiar features of the plastids of the colourless alga Euglena longa and photosynthetic euglenophytes unveiled by transcriptome analyses.Scientific reports · 2018Article
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- De novo assembly and comparative transcriptome analysis of Euglena gracilis in response to anaerobic conditions.BMC genomics · 2016Article
- Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis.BMC plant biology · 2016Article
- RuBisCO in Non-Photosynthetic Alga Euglena longa: Divergent Features, Transcriptomic Analysis and Regulation of Complex Formation.PloS one · 2016Article
- How protein targeting to primary plastids via the endomembrane system could have evolved? A new hypothesis based on phylogenetic studies.Biology direct · 2013Article
- Protein sorting in complex plastids.Biochimica et biophysica acta · 2013Review
- Euglena gracilis and Trypanosomatids possess common patterns in predicted mitochondrial targeting presequences.Journal of molecular evolution · 2012Article
- Plastid origin and evolution: new models provide insights into old problems.Plant physiology · 2011Review
- Sequence evidence for the presence of two tetrapyrrole pathways in Euglena gracilis.Genome biology and evolution · 2011Article
- More membranes, more proteins: complex protein import mechanisms into secondary plastids.Protist · 2010Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plastid of Euglena gracilis was acquired secondarily through an endosymbiotic event with a eukaryotic green alga, and as a result, it is surrounded by a third membrane. This membrane complexity raises the question of how the plastid proteins are targeted to and imported into the organelle. To further explore plastid protein targeting in Euglena, we screened a total of 9,461 expressed sequence tag (EST) clusters (derived from 19,013 individual ESTs) for full-length proteins that are plastid localized to characterize their targeting sequences and to infer potential modes of translocation. Of the 117 proteins identified as being potentially plastid localized whose N-terminal targeting sequences could be inferred, 83 were unique and could be classified into two major groups. Class I proteins have tripartite targeting sequences, comprising (in order) an N-terminal signal sequence, a plastid transit peptide domain, and a predicted stop-transfer sequence. Within this class of proteins are the lumen-targeted proteins (class IB), which have an additional hydrophobic domain similar to a signal sequence and required for further targeting across the thylakoid membrane. Class II proteins lack the putative stop-transfer sequence and possess only a signal sequence at the N terminus, followed by what, in amino acid composition, resembles a plastid transit peptide. Unexpectedly, a few unrelated plastid-targeted proteins exhibit highly similar transit sequences, implying either a recent swapping of these domains or a conserved function. This work represents the most comprehensive description to date of transit peptides in Euglena and hints at the complex routes of plastid targeting that must exist in this organism.
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Registered trials
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