ArticleJournal of bacteriology2006
Mutation in a "tesB-like" hydroxyacyl-coenzyme A-specific thioesterase gene causes hyperproduction of extracellular polyhydroxyalkanoates by Alcanivorax borkumensis SK2.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Polyhydroxyalkanoates as multifaceted biopolymers: an eco-friendly alternative to conventional plastics.RSC advances · 2026Review
- Bioremediation of oil contaminants from the marine ecosystem by Alcanivorax borkumensis: an overview.Archives of microbiology · 2026Review
- Biosurfactant biosynthesis by Alcanivorax borkumensis and its role in oil biodegradation.Nature chemical biology · 2025Article
- A Review of Polyhydroxyalkanoates: Characterization, Production, and Application from Waste.Microorganisms · 2024Review
- Exploring polyhydroxyalkanoates biosynthesis using hydrocarbons as carbon source: a comprehensive review.Biodegradation · 2024Review
- Natural Polyhydroxyalkanoates-An Overview of Bacterial Production Methods.Molecules (Basel, Switzerland) · 2024Review
- High-quality physiology ofFrontiers in bioengineering and biotechnology · 2023Article
- The Glycine-Glucolipid of Alcanivorax borkumensis Is Resident to the Bacterial Cell Wall.Applied and environmental microbiology · 2022Article
- Bioplastics for a circular economy.Nature reviews. Materials · 2022Review
- Beyond oil degradation: enzymatic potential of Alcanivorax to degrade natural and synthetic polyesters.Environmental microbiology · 2020Article
- Development of a CRISPR/Cas9n-based tool for metabolic engineering of Pseudomonas putida for ferulic acid-to-polyhydroxyalkanoate bioconversion.Communications biology · 2020Article
- Beyond Intracellular Accumulation of Polyhydroxyalkanoates: Chiral Hydroxyalkanoic Acids and Polymer Secretion.Frontiers in bioengineering and biotechnology · 2020Review
- Microbial Degradation and Valorization of Plastic Wastes.Frontiers in microbiology · 2020Review
- Production of Polyhydroxyalkanoates and Extracellular Products UsingBioengineering (Basel, Switzerland) · 2019Review
- Prospects for the Use of Whey for Polyhydroxyalkanoate (PHA) Production.Frontiers in microbiology · 2019Review
- Food waste conversion to microbial polyhydroxyalkanoates.Microbial biotechnology · 2017Review
- New family of biosensors for monitoring BTX in aquatic and edaphic environments.Microbial biotechnology · 2016Article
- Marine hydrocarbonoclastic bacteria as whole-cell biosensors for n-alkanes.Microbial biotechnology · 2015Article
- Article
- Bacterial Diversity Associated with the Coccolithophorid Algae Emiliania huxleyi and Coccolithus pelagicus f. braarudii.BioMed research international · 2015Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel mutant of the marine oil-degrading bacterium Alcanivorax borkumensis SK2, containing a mini-Tn5 transposon disrupting a "tesB-like" acyl-coenzyme A (CoA) thioesterase gene, was found to hyperproduce polyhydroxyalkanoates (PHA), resulting in the extracellular deposition of this biotechnologically important polymer when grown on alkanes. The tesB-like gene encodes a distinct novel enzyme activity, which acts exclusively on hydroxylated acyl-CoAs and thus represents a hydroxyacyl-CoA-specific thioesterase. Inactivation of this enzyme results in the rechanneling of CoA-activated hydroxylated fatty acids, the cellular intermediates of alkane degradation, towards PHA production. These findings may open up new avenues for the development of simplified biotechnological processes for the production of PHA as a raw material for the production of bioplastics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.