ArticleBiophysical journal2006
Antimicrobial peptides temporins B and L induce formation of tubular lipid protrusions from supported phospholipid bilayers.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 105 citations in OpenAlex.
- Predicting peptide orientation in membrane interactions: a review on transmembrane and surface-bound states.European biophysics journal : EBJ · 2026Review
- Coupling liquid phases in 3D condensates and 2D membranes: Successes, challenges, and tools.Biophysical journal · 2024Review
- VP2 mediates the release of the feline calicivirus RNA genome by puncturing the endosome membrane of infected cells.Journal of virology · 2024Article
- Stability of multilamellar lipid tubules in excess water.European biophysics journal : EBJ · 2023Article
- Temporins: Multifunctional Peptides from Frog Skin.International journal of molecular sciences · 2023Review
- Evaluation of the Synthetic Multifunctional Peptide Hp-MAP3 Derivative of Temporin-PTa.Toxins · 2023Article
- The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils.Nature communications · 2022Article
- Kassporin-KS1: A Novel Pentadecapeptide from the Skin Secretion ofAntibiotics (Basel, Switzerland) · 2022Article
- Synergistic Action of Antimicrobial Lung Proteins againstInternational journal of molecular sciences · 2021Article
- Structure and Formation Mechanism of Antimicrobial Peptides Temporin B- and L-Induced Tubular Membrane Protrusion.International journal of molecular sciences · 2021Article
- FtsZ Interactions and Biomolecular Condensates as Potential Targets for New Antibiotics.Antibiotics (Basel, Switzerland) · 2021Review
- The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure.Nature communications · 2020Article
- How Membrane Geometry Regulates Protein Sorting Independently of Mean Curvature.ACS central science · 2020Article
- Synthetic cell division via membrane-transforming molecular assemblies.BMC biology · 2019Review
- Peptide-Lipid Interaction Sites Affect Vesicles' Responses to Antimicrobial Peptides.Biophysical journal · 2018Article
- An image-processing method to detect sub-optical features based on understanding noise in intensity measurements.European biophysics journal : EBJ · 2018Article
- Stromules: Probing Formation and Function.Plant physiology · 2018Review
- Article
- Shape Transformations of Lipid Bilayers Following Rapid Cholesterol Uptake.Biophysical journal · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The binding of the antimicrobial peptides temporins B and L to supported lipid bilayer (SLB) model membranes composed of phosphatidylcholine and phosphatidylglycerol (4:1, mol/mol) caused the formation of fibrillar protrusions, visible by fluorescent microscopy of both a fluorescent lipid analog and a labeled peptide. Multicolor imaging at low peptide-to-lipid ratios (P/L < approximately 1:5) revealed an initial in-plane segregation of membrane-bound peptide and partial exclusion of lipid from the peptide-enriched areas. Subsequently, at higher P/L numerous flexible lipid fibrils were seen growing from the areas enriched in lipid. The fibrils have diameters <250 nm and lengths of up to approximately 1 mm. Fibril formation reduces the in-plane heterogeneity and results in a relatively even redistribution of bound peptide over the planar bilayer and the fibrils. Physical properties of the lipid fibrils suggest that they have a tubular structure. Our data demonstrate that the peptide-lipid interactions alone can provide a driving force for the spontaneous membrane shape transformations leading to tubule outgrowth and elongation. Further experiments revealed the importance of positive curvature strain in the tubulation process as well as the sufficient positive charge on the peptide (>/=+2). The observed membrane transformations could provide a simplified in vitro model for morphogenesis of intracellular tubular structures and intercellular connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.