Evidence map›Paper›PMID 16997530›Full record

ArticleGenomics2007

A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes.

William J Murphy, Brian Davis, Victor A David, Richa Agarwala, Alejandro A Schäffer, Alison J Pearks Wilkerson, Beena Neelam, Stephen J O'Brien, Marilyn Menotti-Raymond

Abstract readComparative Study
In one paragraph

Article in Genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 64 citations in OpenAlex.

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  8. Rapid divergence and expansion of the X chromosome in papaya.Proceedings of the National Academy of Sciences of the United States of America · 2012
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  19. Physical mapping of the elephant X chromosome: conservation of gene order over 105 million years.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

William J MurphyDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A & M University, Mail Stop 4458, College Station, TX 77843, USA. wmurphy@cvm.tamu.edu
Brian Davis
Victor A David
Richa Agarwala
Alejandro A Schäffer
Alison J Pearks Wilkerson
Beena Neelam
Stephen J O'Brien
Marilyn Menotti-Raymond
Frederick National Laboratory for Cancer Research · USTexas A&M University · USNational Institutes of Health · USNational Cancer Institute · US

Funding

Comparative Genomics of Genes on Chromosomes X and YZ01SC010370 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI O'BRIEN, STEPHEN J · 2001 to 2008
$2.0M
The Development of the Domestic Cat, IFelis catusI, as an Animal Model for GenetZ01BC005385 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI O'BRIEN, STEPHEN J · 1996 to 2008
$1.6M
Case Studies In GeneticsZ01LM000097 · NLM · NATIONAL LIBRARY OF MEDICINE · PI SCHAFFER, ALEJANDRO A · 2002 to 2008
$452k
NCBI Production Resource DevelopmentZ01LM000160 · NLM · NATIONAL LIBRARY OF MEDICINE · PI OSTELL, JAMES M · 2002 to 2006
–
Intramural NIH HHS Z01 BC005385Intramural NIH HHS Z01 LM000097NCI NIH HHS N01 CO012400NCI NIH HHS N01-CO-12400
6 · The paper itself

Abstract

We report the construction of a 1.5-Mb-resolution radiation hybrid map of the domestic cat genome. This new map includes novel microsatellite loci and markers derived from the 2X genome sequence that target previous gaps in the feline-human comparative map. Ninety-six percent of the 1793 cat markers we mapped have identifiable orthologues in the canine and human genome sequences. The updated autosomal and X-chromosome comparative maps identify 152 cat-human and 134 cat-dog homologous synteny blocks. Comparative analysis shows the marked change in chromosomal evolution in the canid lineage relative to the felid lineage since divergence from their carnivoran ancestor. The canid lineage has a 30-fold difference in the number of interchromosomal rearrangements relative to felids, while the felid lineage has primarily undergone intrachromosomal rearrangements. We have also refined the pseudoautosomal region and boundary in the cat and show that it is markedly longer than those of human or mouse. This improved RH comparative map provides a useful tool to facilitate positional cloning studies in the feline model.

Indexed as

Radiation Hybrid MappingAnimalsBiological EvolutionCatsChromosomes, Human, XDogsGenetic MarkersGenomeGenome, HumanGenomicsHumansMicrosatellite RepeatsSpecies SpecificityX ChromosomeGenetic Markers

Identifiers

PMID16997530
PMCPMC3760348
OpenAlexW2149004854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.