ReviewJournal of molecular evolution1990
Ribonucleic acids may be catalysts for the preferential synthesis of L-amino acid peptides: a minireview.
Review in Journal of molecular evolution, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- The RNA world on ice: a new scenario for the emergence of RNA information.Journal of molecular evolution · 2005Review
- Catalytic roles of the AMP at the 3' end of tRNAs.Molecular and cellular biochemistry · 1994Article
- Couplings of character and of chirality in the origin of the genetic system.Journal of molecular evolution · 1993Article
- Preferential hydrophobic interactions are responsible for a preference of D-amino acids in the aminoacylation of 5'-AMP with hydrophobic amino acids.Experientia · 1992Article
- Experimental studies on the origin of the genetic code and the process of protein synthesis: a review update.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1992Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This minireview is a summary of the basic concepts and pieces of experimental evidence supporting a hypothesis that suggests a mechanism whereby purine monoribonucleotides having D-ribose may be able to preferentially catalyze the synthesis of L-amino acid peptides. The proposed mechanism involves a 2'-3' diaminoacyl intermediate and the preference accrues from several factors that favor the L-isomer, principally for hydrophobic amino acids. Although the hypothesis has not been fully tested, some crucial evidence has been published. Other pieces of evidence are now being submitted or are in press for publication and still other experiments, principally on the step of peptide bond formation, are in the process of being carried out. The purpose of a review at this point is to present the hypothesis to the scientific community in hopes of generating discussion, suggestions, and evaluation by other workers. Should the hypothesis prove correct, it may represent the most primitive and fundamental relationship between the nucleic acid and protein systems. In addition, it would represent another important example of the catalytic ability of RNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.