ArticleJournal of cellular and molecular medicine
Interstitial Cajal-like cells (ICLC) as steroid hormone sensors in human myometrium: immunocytochemical approach.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Morphological evidence of telocytes in DHEA-induced polycystic ovary syndrome model.Histology and histopathology · 2026Article
- Regulation of PDGFRαHeliyon · 2024Article
- Estradiol enhances T-type calcium channel activation in human myometrium telocytes.The Journal of reproduction and development · 2023Article
- Functional Morphology of the Human Uterine Tubes in the 21st Century: Anatomical Novelties and Their Possible Clinical Applications.Physiological research · 2022Article
- Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications.Life (Basel, Switzerland) · 2022Review
- Review and Study of Uterine Bioelectrical Waveforms and Vector Analysis to Identify Electrical and Mechanosensitive Transduction Control Mechanisms During Labor in Pregnant Patients.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Article
- Telocytes enhanced the proliferation, adhesion and motility of endometrial stromal cells as mediated by the ERK pathway in vitro.American journal of translational research · 2019Article
- Uterine EMG activity in the non-pregnant sow during estrous cycle.BMC veterinary research · 2018Article
- Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium.International journal of molecular sciences · 2018Article
- C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract.Acta veterinaria Scandinavica · 2017Article
- Biomathematical pattern of EMG signal propagation in smooth muscle of the non-pregnant porcine uterus.PloS one · 2017Article
- Identification and potential role of telocytes in human uterine leiomyoma.Contraception and reproductive medicine · 2016Article
- In vitro morphology, viability and cytokine secretion of uterine telocyte-activated mouse peritoneal macrophages.Journal of cellular and molecular medicine · 2015Article
- Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels.Histochemistry and cell biology · 2015Article
- Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium.Reproduction (Cambridge, England) · 2013Article
- Structural and ultrastructural evidence for telocytes in prostate stroma.Journal of cellular and molecular medicine · 2013Article
- Identification of telocytes in the upper lamina propria of the human urinary tract.Journal of cellular and molecular medicine · 2012Article
- Culture of rat endometrial telocytes.Journal of cellular and molecular medicine · 2012Article
- Unexpected flagellar movement patterns and epithelial binding behavior of mouse sperm in the oviduct.Biology of reproduction · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of estrogen (ER) and progesterone (PR) receptors was investigated in cultured human normal myometrial cells (non-pregnant uterus, fertile period). The ER and PR expression was studied by immunohistochemistry and immunofluorescence on either myocytes or interstitial Cajal-like cells (ICLC). Only those cells double immunostained for c-kit and steroid receptors were considered as ICLC. ER and/or PR immunoreactivity was localized in ICLC, primarily concentrated at the nucleus level, but it was also observed in the cell body (cytoplasm) and processes. Stronger immunopositive reaction in the ICLC nucleus for PR than for ER was noted. Under our experimental conditions, a clear positive repeatable reaction for steroid receptors could not be detected in myocytes. In conclusion, these data suggest that ICLC could be true hormonal 'sensors', possibly participating in the regulation of human myometrial contractions (via gap junctions with myocytes and/or by paracrine signaling).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.