ArticleJournal of cellular and molecular medicine
Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Biological conduits based on spider silk for reconstruction of extended nerve defects.Innovative surgical sciences · 2024Article
- Bacteria inhabiting spider webs enhance host silk extensibility.Scientific reports · 2024Article
- Review of Spider Silk Applications in Biomedical and Tissue Engineering.Biomimetics (Basel, Switzerland) · 2024Review
- Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response.Advanced healthcare materials · 2024Article
- Factors Influencing Properties of Spider Silk Coatings and Their Interactions within a Biological Environment.Journal of functional biomaterials · 2023Review
- Silk-in-Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model.Advanced healthcare materials · 2023Article
- Modulating Surface Properties of theBiomacromolecules · 2021Article
- Preparation of controlled degradation of insulin-like growth factor 1/spider silk protein nanofibrous membrane and its effect on endothelial progenitor cell viability.Bioengineered · 2021Article
- Defining the regenerative effects of native spider silk fibers on primary Schwann cells, sensory neurons, and nerve-associated fibroblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Hybrid Spider Silk with Inorganic Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Review
- Nephila edulis-breeding and care under laboratory conditions.Development genes and evolution · 2020Article
- Spider Silk for Tissue Engineering Applications.Molecules (Basel, Switzerland) · 2020Review
- Recent Advances in Development of Functional Spider Silk-Based Hybrid Materials.Frontiers in chemistry · 2020Review
- Nerve grafting for peripheral nerve injuries with extended defect sizes.Wiener medizinische Wochenschrift (1946) · 2019Review
- Co-Culturing Human Adipose Derived Stem Cells and Schwann Cells on Spider Silk-A New Approach as Prerequisite for Enhanced Nerve Regeneration.International journal of molecular sciences · 2018Article
- Silk micrococoons for protein stabilisation and molecular encapsulation.Nature communications · 2017Article
- Studies on the use of recombinant spider silk protein/polyvinyl alcohol electrospinning membrane as wound dressing.International journal of nanomedicine · 2017Article
- Characterization and Schwann Cell Seeding of up to 15.0 cm Long Spider Silk Nerve Conduits for Reconstruction of Peripheral Nerve Defects.Journal of functional biomaterials · 2016Article
- Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits.International journal of molecular sciences · 2016Review
- Silk-Its Mysteries, How It Is Made, and How It Is Used.ACS biomaterials science & engineering · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defects of peripheral nerves still represent a challenge for surgical nerve reconstruction. Recent studies concentrated on replacement by artificial nerve conduits from different synthetic or biological materials. In our study, we describe for the first time the use of spider silk fibres as a new material in nerve tissue engineering. Schwann cells (SC) were cultivated on spider silk fibres. Cells adhered quickly on the fibres compared to polydioxanone monofilaments (PDS). SC survival and proliferation was normal in Live/Dead assays. The silk fibres were ensheathed completely with cells. We developed composite nerve grafts of acellularized veins, spider silk fibres and SC diluted in matrigel. These artificial nerve grafts could be cultivated in vitro for one week. Histological analysis showed that the cells were vital and formed distinct columns along the silk fibres. In conclusion, our results show that artificial nerve grafts can be constructed successfully from spider silk, acellularized veins and SC mixed with matrigel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.