ReviewJournal of cellular and molecular medicine
What is hidden in the pannexin treasure trove: the sneak peek and the guesswork.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Connexin-Pannexin duality in glioblastoma.Cell and tissue research · 2026Review
- [Down-regulation of pannexin 2 channel enhances cisplatin-induced apoptosis in testicular cancer I-10 cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Exciting and not so exciting roles of pannexins.Neuroscience letters · 2019Review
- Are there gap junctions without connexins or pannexins?BMC evolutionary biology · 2019Article
- Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics.International journal of molecular sciences · 2018Review
- Pannexin3 inhibits TNF-α-induced inflammatory response by suppressing NF-κB signalling pathway in human dental pulp cells.Journal of cellular and molecular medicine · 2017Article
- Connexin and pannexin channels in cancer.BMC cell biology · 2016Review
- Osteoarthritis is what the people have.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?Cellular and molecular life sciences : CMLS · 2015Review
- Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism.The Journal of biological chemistry · 2014Article
- Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membrane.Frontiers in cellular neuroscience · 2014Article
- Pore positioning: current concepts in Pannexin channel trafficking.Channels (Austin, Tex.) · 2014Review
- The pannexins: past and present.Frontiers in physiology · 2014Review
- Biological role of connexin intercellular channels and hemichannels.Archives of biochemistry and biophysics · 2012Review
- Expression and roles of pannexins in ATP release in the pituitary gland.Endocrinology · 2011Article
- Diverse evolutionary paths to cell adhesion.Trends in cell biology · 2010Review
- Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes.American journal of physiology. Heart and circulatory physiology · 2010Article
- Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors, and KATP channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Pannexin2 as a novel growth regulator in C6 glioma cells.Oncogene · 2009Article
- The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release.Purinergic signalling · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connexins had been considered to be the only class of the vertebrate proteins capable of gap junction formation; however, new candidates for this function with no homology to connexins, termed pannexins were discovered. So far three pannexins were described in rodent and human genomes: Panx1, Panx2 and Panx3. Expressions of pannexins can be detected in numerous brain structures, and now found both in neuronal and glial cells. Hypothetical roles of pannexins in the nervous system include participating in sensory processing, hippocampal plasticity, synchronization between hippocampus and cortex, and propagation of the calcium waves supported by glial cells, which help maintain and modulate neuronal metabolism. Pannexin also may participate in pathological reactions of the neural cells, including their damage after ischemia and subsequent cell death. Recent study revealed non-gap junction function of Panx1 hemichannels in erythrocytes, where they serve as the conduits for the ATP release in response to the osmotic stress. High-throughput studies produced some evidences of the pannexin involvement in the process of tumorigenesis. According to brain cancer gene expression database REMBRANDT, PANX2 expression levels can predict post diagnosis survival for patients with glial tumors. Further investigations are needed to verify or reject hypotheses listed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.