Evidence map›Paper›PMID 16989681›Full record

ReviewAnnals of tropical medicine and parasitology2006

Malaria and helminth interactions in humans: an epidemiological viewpoint.

T W Mwangi, J M Bethony, S Brooker

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of tropical medicine and parasitology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 5 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  17. Article
  18. Prevalence of malaria andParasite epidemiology and control · 2025
    Review
  19. Article
  20. Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025
    Review

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

T W MwangiKenya Medical Research Institute, Centre for Geographic Medicine and Research, P.O. Box 230, 80108 Kilifi, Kenya. tmwangi@kilifi.mimcom.net
J M Bethony
S Brooker
Fundação Oswaldo Cruz · BRKenya Medical Research Institute · KELondon School of Hygiene & Tropical Medicine · GB

Funding

INTERNATIONAL RESEARCH SCINTIST DEVELOPEMENT AWARDK01TW000009 · FIC · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI BETHONY, JEFFREY MICHAEL · 2000 to 2005
$612k
FIC NIH HHS K01 TW000009FIC NIH HHS K01 TW00009Wellcome Trust 073656
6 · The paper itself

Abstract

In the tropics, helminths are among the most common chronic infections of humans and Plasmodium infections the most deadly. As these two groups of parasites have similar geographical distributions, co-infection is commonplace. It has increasingly been speculated that helminth infections may alter susceptibility to clinical malaria, and there is now increasing interest in investigating the consequences of co-infection, with studies yielding contrasting results. The immunological interactions between helminths and malarial parasites are unclear, although several hypotheses have been proposed. This review provides an epidemiological overview of the possible interactions between helminths and malarial parasites, in relation to geographical distributions and disease patterns, and provides a critical discussion of the results of the epidemiological studies that have so far been conducted to investigate the possible associations. Future studies that might be considered, in order to address the gaps in knowledge, are also considered.

Indexed as

Africa South of the SaharaAge DistributionAntimalarialsChild, PreschoolClimateComorbidityDisease SusceptibilityFemaleHelminthiasisHumansIncidenceInfantMalariaPregnancyPrevalenceResearch DesignAntimalarials

Identifiers

PMID16989681
PMCPMC1858631
OpenAlexW1995506203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.