Evidence map›Paper›PMID 16988818›Full record

ArticleExperimental brain research2007

Impaired inhibitory oculomotor control in patients with Parkinson's disease.

Prakash Joti, Shrikanth Kulashekhar, Madhuri Behari, Aditya Murthy

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Towards a unifying mechanism for cancelling movements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Frontal-subcortical circuits involved in reactive control and monitoring of gaze.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  13. Article
  14. Article
  15. New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: a clinical review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013
    Review
  16. Queuing of concurrent movement plans by basal ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Prakash JotiNational Brain Research Centre, Nainwal More, Manesar, Haryana 122 050, India.
Shrikanth Kulashekhar
Madhuri Behari
Aditya Murthy
National Brain Research Centre · INAll India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A hallmark of voluntary control is the capacity to inhibit or change partially prepared responses, an ability thought to be compromised in patients with Parkinson's disease (PD). To test this hypothesis in relation to oculomotor control, PD patients and age-matched controls performed a redirect task in which they were instructed to cancel a partially prepared saccade on some random fraction of trials. Using a race model framework, the time it takes to cancel a saccade, the target switch reaction time (TSRT), was estimated for PD and control subjects. While saccadic reaction times of control and PD subjects were similar, the average TSRT in PD subjects was 139 ms, and was significantly greater than the TSRT in controls, which was 113 ms. These results support the hypothesis that poor voluntary control exhibited by PD patients in a variety of complex behaviors may be caused by impaired inhibitory control as a result of basal ganglia dysfunction.

Indexed as

AdultAgedBasal GangliaFemaleHumansMaleMiddle AgedNeural InhibitionNeural PathwaysOcular Motility DisordersOculomotor MusclesParkinson DiseasePhotic StimulationReaction TimeSaccades

Identifiers

PMID16988818
OpenAlexW2039576407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.