ArticleInfection and immunity2006
Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- In Search of a Mechanistic Link between Chlamydia trachomatis-Induced Cellular Pathophysiology and Oncogenesis.Infection and immunity · 2023Review
- Deregulation of the cyclin-dependent kinase inhibitor p27 as a putative candidate for transformation inAIMS microbiology · 2023Article
- Aberrant gene expression of superoxide dismutases in Chlamydia trachomatis-infected recurrent spontaneous aborters.Scientific reports · 2022Article
- TheMicroorganisms · 2019Article
- Early Transcriptional Landscapes ofFrontiers in cellular and infection microbiology · 2019Article
- Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.Scientific reports · 2015Article
- Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth.Cell host & microbe · 2014Article
- Chlamydial infection induces host cytokinesis failure at abscission.Cellular microbiology · 2012Article
- CPAF: a Chlamydial protease in search of an authentic substrate.PLoS pathogens · 2012Article
- The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly.The Journal of biological chemistry · 2011Article
- Chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification.Traffic (Copenhagen, Denmark) · 2011Article
- Functional interaction between type III-secreted protein IncA of Chlamydophila psittaci and human G3BP1.PloS one · 2011Article
- Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways.Frontiers in microbiology · 2011Article
- Killing me softly: chlamydial use of proteolysis for evading host defenses.Trends in microbiology · 2009Review
- Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223.BMC microbiology · 2009Article
- Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The obligate intracellular pathogen Chlamydia trachomatis interferes with a number of host cell processes, including cytoskeletal organization, vesicular trafficking, and apoptosis. In this study we report that C. trachomatis-infected cells proliferate more slowly than uninfected cells, suggesting that C. trachomatis may also manipulate the eukaryotic cell cycle. We further demonstrate that C. trachomatis infection destabilizes specific cell cycle proteins involved in the G2/M transition. C. trachomatis-infected cells, compared to uninfected cells, have lower levels of cyclin-dependent kinase 1. Additionally, C. trachomatis infection induces an N-terminal truncation of the mitotic cyclin B1. Manipulation of the host cell cycle may represent a strategy used by C. trachomatis to ensure a stable environment conducive to bacterial growth and replication.
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