ArticleInfection and immunity2006
The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 67 citations in OpenAlex.
- Adaptation mechanisms of Brucella abortus to low magnesium ion stress.BMC veterinary research · 2025Article
- AliC and AliD of nonencapsulatedFrontiers in cellular and infection microbiology · 2025Article
- Impact of MgtC on the Fitness ofPathogens (Basel, Switzerland) · 2023Article
- An evolutionary conserved detoxification system for membrane lipid-derived peroxyl radicals in Gram-negative bacteria.PLoS biology · 2022Article
- Virulence Mechanisms ofFrontiers in microbiology · 2022Review
- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.Nature reviews. Microbiology · 2020Review
- Synthetic hydrophobic peptides derived from MgtR weaken Salmonella pathogenicity and work with a different mode of action than endogenously produced peptides.Scientific reports · 2019Article
- The Salmonella virulence protein MgtC promotes phosphate uptake inside macrophages.Nature communications · 2019Article
- Activity of a Synthetic Peptide Targeting MgtC onFrontiers in cellular and infection microbiology · 2019Article
- A rule governing the FtsH-mediated proteolysis of the MgtC virulence protein from Salmonella enterica serovar Typhimurium.Journal of microbiology (Seoul, Korea) · 2018Article
- Article
- Enhanced succinic acid productivity by expression of mgtCB gene in Escherichia coli mutant.Journal of industrial microbiology & biotechnology · 2016Article
- Intramacrophage Survival for Extracellular Bacterial Pathogens: MgtC As a Key Adaptive Factor.Frontiers in cellular and infection microbiology · 2016Article
- Regulation and function of the Salmonella MgtC virulence protein.Journal of microbiology (Seoul, Korea) · 2015Review
- When Too Much ATP Is Bad for Protein Synthesis.Journal of molecular biology · 2015Review
- A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens.PLoS pathogens · 2015Article
- Salmonella promotes virulence by repressing cellulose production.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Control of a Salmonella virulence operon by proline-charged tRNA(Pro).Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mycobacterium marinum MgtC plays a role in phagocytosis but is dispensable for intracellular multiplication.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burkholderia cenocepacia, a bacterium commonly found in the environment, is an important opportunistic pathogen in patients with cystic fibrosis (CF). Very little is known about the mechanisms by which B. cenocepacia causes disease, but chronic infection of the airways in CF patients may be associated, at least in part, with the ability of this bacterium to survive within epithelial cells and macrophages. Survival in macrophages occurs in a membrane-bound compartment that is distinct from the lysosome, suggesting that B. cenocepacia prevents phagolysosomal fusion. In a previous study, we employed signature-tagged mutagenesis and an agar bead model of chronic pulmonary infection in rats to identify B. cenocepacia genes that are required for bacterial survival in vivo. One of the most significantly attenuated mutants had an insertion in the mgtC gene. Here, we show that mgtC is also needed for growth of B. cenocepacia in magnesium-depleted medium and for bacterial survival within murine macrophages. Using fluorescence microscopy, we demonstrated that B. cenocepacia mgtC mutants, unlike the parental isolate, colocalize with the fluorescent acidotropic probe LysoTracker Red. At 4 h postinfection, mgtC mutants expressing monomeric red fluorescent protein cannot retain this protein within the bacterial cytoplasm. Together, these results demonstrate that, unlike the parental strain, an mgtC mutant does not induce a delay in phagolysosomal fusion and the bacterium-containing vacuoles are rapidly targeted to the lysosome, where bacteria are destroyed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.