ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 173 citations in OpenAlex.
- Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives.MedComm · 2026Review
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- Promoter mutagenesis and a massively parallel reporter screen of thebioRxiv : the preprint server for biology · 2026Article
- Myelin development in the peripheral nervous system ofFrontiers in cell and developmental biology · 2026Article
- Advances in multiscale myelin imaging: from classical histology to functional insights.Frontiers in cellular neuroscience · 2026Review
- Dock1 functions in Schwann cells to regulate development, maintenance, and repair.The Journal of cell biology · 2025Article
- The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells.Cell reports · 2025Article
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- Schwann Cell Development and Myelination.Cold Spring Harbor perspectives in biology · 2024Review
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- Transcription Factor BCL11A Regulates Schwann Cell Behavior During Peripheral Nerve Regeneration.Molecular neurobiology · 2023Article
- Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue.iScience · 2023Article
- Review
- The proteome of distal nerves: implication in delayed repair and poor functional recovery.Neural regeneration research · 2022Article
- Disruption of Endosomal Sorting in Schwann Cells Leads to Defective Myelination and Endosomal Abnormalities Observed in Charcot-Marie-Tooth Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling.Frontiers in cell and developmental biology · 2022Article
- Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells.Bioengineering & translational medicine · 2022Article
- Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging.Biomolecules · 2021Review
- Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Onset of myelination in Schwann cells is governed by several transcription factors, including Krox20/Egr2, and mutations affecting Krox20 result in various human hereditary peripheral neuropathies, including congenital hypomyelinating neuropathy (CHN) and Charcot-Marie-Tooth disease (CMT). Similar molecular information is not available on the process of myelin maintenance. We have generated conditional Krox20 mutations in the mouse that allowed us to develop models for CHN and CMT. In the latter case, specific inactivation of Krox20 in adult Schwann cells results in severe demyelination, involving rapid Schwann cell dedifferentiation and increased proliferation, followed by an attempt to remyelinate and a block at the promyelinating stage. These data establish that Krox20 is not only required for the onset of myelination but that it is also crucial for the maintenance of the myelinating state. Furthermore, myelin maintenance appears as a very dynamic process in which Krox20 may constitute a molecular switch between Schwann cell myelination and demyelination programs.
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