ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction.Biological psychiatry · 2025Article
- Epigenome-wide study of brain DNA methylation following acute opioid intoxication.Drug and alcohol dependence · 2021Article
- Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions.Cold Spring Harbor perspectives in biology · 2018Review
- Oxycodone Self-Administration Induces Alterations in Expression of Integrin, Semaphorin and Ephrin Genes in the Mouse Striatum.Frontiers in psychiatry · 2018Article
- Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review.Clinical and experimental gastroenterology · 2012Article
- Transcriptional and epigenetic regulation of opioid receptor genes: present and future.Annual review of pharmacology and toxicology · 2011Review
- Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons.RNA (New York, N.Y.) · 2010Article
- Dynamics of axonal mRNA transport and implications for peripheral nerve regeneration.Experimental neurology · 2010Review
- Kappa opioid receptor contributes to EGF-stimulated neurite extension in development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA.The Journal of cell biology · 2010Article
- Dynein motor contributes to stress granule dynamics in primary neurons.Neuroscience · 2009Article
- A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins.Molecular and cellular neurosciences · 2009Article
- Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.The EMBO journal · 2008Article
- Article
- Function and regulation of local axonal translation.Current opinion in neurobiology · 2008Review
- Endogenous opiates and behavior: 2006.Peptides · 2007Review
- Local translation and directional steering in axons.The EMBO journal · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The expression of kappa opioid receptor (KOR) is subjected to both transcriptional and posttranscriptional controls. We report that KOR translation is regulated by netrin-1 in primary neurons of dorsal root ganglion (DRG) and in P19 embryonal carcinoma cells. Without stimulation, a significant portion of KOR mRNA is maintained in a dormant state and partitions in the translationally inactive, post-polysomal fraction. During netrin-1 stimulation, which activates its downstream target focal adhesion kinase (FAK), KOR mRNA rapidly partitions to the translationally active polysomal fraction. Functionally, the newly synthesized KOR proteins in DRG neurons are able to bind to specific ligands. This report describes the first example of netrin-1 signaling in the translational control of a drug receptor KOR, which involves the mediator of netrin-1, FAK, and a novel mechanism that enhances the association of target mRNA with polysomes for translational activation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.