ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Area postrema neurons are modulated by the adipocyte hormone adiponectin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 96 citations in OpenAlex.
- Adipokine in Metabolic Liver Disease: Adipo-Brain-Liver Cross talk.International journal of endocrinology · 2026Review
- Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity.Clinical nutrition research · 2024Article
- Adiponectin: friend or foe in obesity and inflammation.Medical review (2021) · 2022Review
- Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation.Metabolites · 2021Review
- Regulation of diurnal energy balance by mitokines.Cellular and molecular life sciences : CMLS · 2021Review
- Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels.Journal of psychiatric research · 2020Article
- Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer's Dementia.Frontiers in physiology · 2020Review
- The Novel Perspectives of Adipokines on Brain Health.International journal of molecular sciences · 2019Review
- Adiponectin improves long-term potentiation in the 5XFAD mouse brain.Scientific reports · 2019Article
- Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Associations of cord blood leptin and adiponectin with children's cognitive abilities.Psychoneuroendocrinology · 2019Article
- Cardiovascular Autonomic Dysfunction: Link Between Multiple Sclerosis Osteoporosis and Neurodegeneration.Neuromolecular medicine · 2018Review
- Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1.EBioMedicine · 2017Article
- Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease.International journal of molecular sciences · 2017Review
- Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.Journal of neuroinflammation · 2016Review
- Physiological roles for the subfornical organ: a dynamic transcriptome shaped by autonomic state.The Journal of physiology · 2016Review
- PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation.FEBS letters · 2015Article
- Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study.Cell death & disease · 2015Article
- Article
- Obesity and dementia: adipokines interact with the brain.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood-brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced membrane properties of AP neurons and found that approximately 60% of rat AP neurons tested were sensitive to adiponectin. Additional electrophysiology experiments coupled with single-cell reverse transcription-PCR indicated that all neurons that expressed both subtypes of receptor were sensitive to adiponectin, whereas neurons expressing only one subtype were predominantly insensitive. Last, microinjection of adiponectin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.