ArticleThe British journal of ophthalmology2007
Effect of verteporfin photodynamic therapy on endostatin and angiogenesis in human choroidal neovascular membranes.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular Determinants for Photodynamic Therapy Resistance and Improved Photosensitizer Delivery in Glioma.International journal of molecular sciences · 2024Review
- Histone deacetylase inhibitor attenuates experimental fungal keratitis in mice.Scientific reports · 2019Article
- Choroidal morphology and short-term outcomes of combination photodynamic therapy in polypoidal choroidal vasculopathy.Eye (London, England) · 2019Article
- The Efficiency of Verteporfin as a Therapeutic Option in Pre-Clinical Models of Melanoma.Journal of Cancer · 2019Article
- Co-Administered Polymeric Nano-Antidotes for Improved Photo-Triggered Response in Glioblastoma.Pharmaceutics · 2018Article
- Incidence, outcomes, and risk factors for hemorrhagic complications in eyes with polypoidal choroidal vasculopathy following photodynamic therapy in Indian subjects.Indian journal of ophthalmology · 2017Article
- Polypoidal Choroidal Vasculopathy.Current ophthalmology reports · 2017Article
- Polypoidal Choroidal Vasculopathy in Asians.Journal of clinical medicine · 2015Review
- Polymorphisms in the VEGF-A in polypoidal choroidal vasculopathy in a Korean population.Japanese journal of ophthalmology · 2012Article
- Matrix metalloproteinases in human choroidal neovascular membranes excised following verteporfin photodynamic therapy.The British journal of ophthalmology · 2007Article
- Towards a rational approach to combination therapy for neovascular age-related macular degeneration.The British journal of ophthalmology · 2007Article
- Combination therapy for choroidal neovascularisation.Drugs & aging · 2007Article
- Polypoidal choroidal vasculopathy: An update on current management and review of literature.Taiwan journal of ophthalmologyReview
Corrections and comments
- Commented on by
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effect of verteporfin photodynamic therapy (PDT) on endostatin with regard to expression of vascular endothelial growth factor (VEGF) in human choroidal neovascular membranes (CNVs) secondary to age-related macular degeneration.
methodsA retrospective review of an interventional case series of 68 patients who underwent removal of CNV. 29 patients were treated with PDT 3-655 days before surgery. 39 CNVs without previous treatment were used as controls. CNVs were stained for CD34, CD105, Ki-67, cytokeratin 18, endostatin, E-selectin and VEGF. "Predominance score of VEGF over endostatin" (mean) was defined as the difference between VEGF and endostatin staining scores.
resultsIn four CNVs treated by PDT 3 days previously, PS was significantly higher in the retinal pigment epithelium (mean = 2.5, p = 0.006) and stroma (mean = 2, p = 0.015) than in the control group (mean = 0). At longer post-PDT intervals, PS was significantly decreased in the retinal pigment epithelium (mean = 0, p = 0.019) and stroma (mean = 0, p = 0.015). Proliferative activity was high (p = 0.023), but mostly related to inflammatory cells. PDT did not influence E-selectin expression significantly.
conclusionsVEGF predominance over endostatin early after PDT might contribute to enhanced angiogenic activity associated with recurrences. Strategies upregulating or replacing endostatin early after PDT might increase the effectiveness of PDT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.