ArticleCell proliferation2006
An enteroendocrine cell-based model for a quiescent intestinal stem cell niche.
Article in Cell proliferation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Article
- Article
- Article
- Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.Mucosal immunology · 2018Review
- Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche.Stem cells international · 2017Review
- Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells.BMC cancer · 2016Article
- The regulatory niche of intestinal stem cells.The Journal of physiology · 2016Review
- Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cultivated in serum-free medium.Oncology letters · 2016Article
- Aging of the mammalian gastrointestinal tract: a complex organ system.Age (Dordrecht, Netherlands) · 2014Review
- A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt.PLoS computational biology · 2011Article
- Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Intestinal crypt properties fit a model that incorporates replicative ageing and deep and proximate stem cells.Cell proliferation · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown that the kinetics of conversion of intestinal crypt cell populations to a partially or wholly mutant phenotype are consistent with a model in which each crypt contains an infrequently dividing 'deep' stem cell that is the progenitor of several more frequently dividing 'proximate' stem cells. An assumption of our model is that each deep stem cell exists in a growth inhibitory niche. We have used information from the literature to develop a model for a quiescent intestinal stem cell niche. This niche is postulated to be primarily defined by an enteroendocrine cell type that maintains stem cell quiescence by secretion of growth inhibitory peptides such as somatostatin and guanylin/uroguanylin. Consistent with this model, there is evidence that the proteins postulated as defining a growth-inhibitory stem cell niche can act as intestinal tumour suppressors. Confirmation that a growth-inhibitory niche does exist would have important implications for our understanding of intestinal homeostasis and tumorigenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.