ArticleCell proliferation2006
Intestinal crypt properties fit a model that incorporates replicative ageing and deep and proximate stem cells.
Article in Cell proliferation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Aging of the mammalian gastrointestinal tract: a complex organ system.Age (Dordrecht, Netherlands) · 2014Review
- Heterogeneity of the level of activity of lgr5+ intestinal stem cells.International journal of molecular and cellular medicine · 2014Review
- Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.Nature · 2011Article
- An integrative computational model for intestinal tissue renewal.Cell proliferation · 2009Article
- Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Towards a multiscale model of colorectal cancer.World journal of gastroenterology · 2007Review
- An enteroendocrine cell-based model for a quiescent intestinal stem cell niche.Cell proliferation · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A model of intestinal crypt organization is suggested based on the assumption that stem cells have a finite replicative life span. The model assumes the existence in a crypt of a quiescent ('deep') stem cell and a few more actively cycling ('proximate') stem cells. Monte Carlo computer simulation of published intestinal crypt mutagenesis data is used to test the model. The results of the simulation indicate that stabilization of the crypt mutant phenotype following treatment with external mutagen is consistent with a stem cell replicative life span of about 40 divisions for mouse colon and 90-100 divisions for mouse small intestine, corresponding to a deep stem cell cycle time of about 3.9 and 8.5 weeks for colon and small intestine, respectively. Simulation of the data obtained for human colorectal crypts suggests that the proximate stem cell cycle time is about 80 h, assuming a replicative life span of 50-150 divisions, and that the deep stem cell divides approximately every 30 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.