ArticleThe EMBO journal1990
T cell precursor migration towards beta 2-microglobulin is involved in thymus colonization of chicken embryos.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Three-Dimensional Avian Hematopoietic Stem Cell Cultures as a Model for Studying Disease Pathogenesis.Frontiers in cell and developmental biology · 2021Review
- CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.PloS one · 2012Article
- Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves.The Journal of experimental medicine · 1997Article
- HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors.The Journal of cell biology · 1996Article
- The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- T cell migration during development: homing is not related to TCR V beta 1 repertoire selection.The EMBO journal · 1994Article
- Thymic origin of embryonic intestinal gamma/delta T cells.The Journal of experimental medicine · 1993Article
- Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection.Immunogenetics · 1993Article
- Cloning of the beta 2-microglobulin gene in the zebrafish.Immunogenetics · 1993Article
- Emergence of committed B lymphoid progenitors in the developing chicken embryo.The EMBO journal · 1992Article
- EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus.The Journal of cell biology · 1991Article
- Chicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune system.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Functional histology of the human thymus.Anatomy and embryology · 1991Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta 2-microglobulin (beta 2m) attracts hemopoietic precursors from chicken bone marrow cells in vitro. The cell population responding to beta 2m increases during the second period of thymus colonization, which takes place at days 12-14 of incubation. The precursors from 13.5 day old embryos were isolated after migration towards beta 2m in vitro and shown to be able to colonize a 13 day old thymus in ovo, where they subsequently acquire thymocyte markers. In contrast these beta 2m responsive precursors did not colonize embryonic bursa, i.e. differentiate into B lymphocytes. During chicken embryogenesis, peaks of beta 2m transcripts and of free beta 2m synthesis can only be detected in the thymus. The peak of free beta 2m synthesis in the thymus and the increase of beta 2m responding bone marrow cells both occur concomitantly with the second wave of thymus colonization in chicken embryo, facts which suggest that beta 2m mediated chemotaxis is involved in the second wave.
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