ArticleThe EMBO journal1990
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 296 citations in OpenAlex.
- A transcriptional signature of resting mast cells is associated with improved disease outcome in HRGenes and immunity · 2026Article
- Mastocytosis.Nature reviews. Disease primers · 2025Review
- Autocrine/Paracrine Loop Between SCFFrontiers in immunology · 2022Article
- Mast Cell Biology at Molecular Level: a Comprehensive Review.Clinical reviews in allergy & immunology · 2020Review
- Successful treatment with avapritinib in patient with mucosal metastatic melanoma.Therapeutic advances in medical oncology · 2020Article
- Mast Cells in Liver Fibrogenesis.Cells · 2019Review
- Comparison of Human Hematopoietic Reconstitution in Different Strains of Immunodeficient Mice.Stem cells and development · 2017Article
- c-Kit-Positive Adipose Tissue-Derived Mesenchymal Stem Cells Promote the Growth and Angiogenesis of Breast Cancer.BioMed research international · 2017Article
- Suppression of c-Kit signaling induces adult neurogenesis in the mouse intestine after myenteric plexus ablation with benzalkonium chloride.Scientific reports · 2016Article
- Mast cells in airway diseases and interstitial lung disease.European journal of pharmacology · 2016Review
- ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.Oncotarget · 2016Article
- Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice.Journal of visualized experiments : JoVE · 2015Article
- Dendritic cell c-kit signaling and adaptive immunity: implications for the upper airways.Current opinion in allergy and clinical immunology · 2014Review
- KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion.Stem cells (Dayton, Ohio) · 2013Article
- Ex vivo evaluation of imatinib mesylate for induction of cell death on canine neoplastic mast cells with mutations in c-Kit exon 11 via apoptosis.Veterinary research communications · 2013Article
- Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Oestrogen-deficiency inducing haematopoiesis dysfunction via reduction in haematopoietic stem cells and haematopoietic growth factors in rats.International journal of experimental pathology · 2012Article
- Citreorosein inhibits degranulation and leukotriene C₄ generation through suppression of Syk pathway in mast cells.Molecular and cellular biochemistry · 2012Article
- Article
- Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans.Frontiers in immunology · 2012Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The c-kit proto-oncogene encodes a transmembrane tyrosine kinase receptor for an unidentified ligand and is allelic with the murine white-spotting locus (W). W mutations affect melanogenesis, gametogenesis and hematopoiesis during development and in adult life. Cellular targets of W mutations in hematopoiesis include distinct cell populations in the erythroid and mast cell lineages as well as stem cells. In the absence of interleukin-3 (IL-3) mast cells derived from normal mice but not from W mutant mice can be maintained by co-culture with 3T3 fibroblasts. Based on the defective proliferative response of W mast cells in the 3T3 fibroblast co-culture system it had been proposed that fibroblasts produce the c-kit ligand. We have used a mast cell proliferation assay to purify a 30 kd protein, designated KL, from conditioned medium of Balb/3T3 fibroblasts to apparent homogeneity. KL stimulates the proliferation of normal bone marrow derived mast cells but not mast cells from W mice, although both normal and mutant mast cells respond similarly to IL-3. Connective tissue-type mast cells derived from the peritoneal cavity of normal mice were found to express a high level of c-kit protein on their surface and to proliferate in response to KL. The effect of KL on erythroid progenitor cells was investigated as well. In combination with erythropoietin, KL was found to stimulate early erythroid progenitors (BFU-E) from fetal liver and spleen cells but not from bone marrow cells of adult mice and from fetal liver cells of W/W mice.(ABSTRACT TRUNCATED AT 250 WORDS)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.