Evidence map›Paper›PMID 16984980›Full record

SynthesisArchives of disease in childhood. Fetal and neonatal edition2007

Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis.

Clare M Rees, Agostino Pierro, Simon Eaton

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 160 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 10 pooled it
12.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02552706 naunknown statusnot on this mapstarted 2014, after this paper: background citation

The Efficacy and Mechanisms of Oral Probiotics in Preventing Necrotizing Enterocolitis Among Very Low Birth Weight Infants With Formula-feeding

TypeinterventionalSponsorShenzhen Bao'an Maternal and Child Health HospitalRan2014 to 2017Enrolled270ConditionsNecrotizing Enterocolitis, DeathArmsprobiotics, glucose solution
NCT05213806 narecruitingnot on this mapstarted 2022, after this paper: background citation

The WHEAT International Trial: WithHolding Enteral Feeds Around Red Cell Transfusion to Prevent Necrotizing Enterocolitis in Preterm Neonates: an International, Multi-centre, Randomized Controlled Trial

TypeinterventionalSponsorIWK Health CentreRan2022 to 2027Enrolled4,333ConditionsNecrotizing EnterocolitisArmsWithholding feeds around transfusion, Continued feeds around transfusion
3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 10 syntheses or guidelines pooled it, 418 citations in OpenAlex.

  1. Pooled it
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  3. Early full enteral feeding for preterm or low birth weight infants.The Cochrane database of systematic reviews · 2020
    Pooled it
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  11. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study.Archives of disease in childhood. Fetal and neonatal edition · 2023
    Trial
  12. Economic evaluation alongside the Speed of Increasing milk Feeds Trial (SIFT).Archives of disease in childhood. Fetal and neonatal edition · 2020
    Trial
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100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Clare M ReesDepartment of Paediatric Surgery, Institute of Child Health, London, UK.
Agostino Pierro
Simon Eaton
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives(1) To characterise neurodevelopmental outcome of neonates with necrotizing enterocolitis (NEC); (2) to define whether NEC increases risk of neurodevelopmental impairment in very low birth weight neonates; (3) to investigate whether stage of disease or need for surgery increase risk of poor outcome.

designA systematic review was performed. Searches identified 182 relevant papers. Ten studies compared extremely low birthweight neonates with NEC to infants of similar age and gestation who did not develop NEC. Data are reported as OR (95% CIs, p values for test for overall effect) and compared by chi2.

results7843 children (821 with NEC) were included in the meta-analysis. Median follow-up was 20 months (range 12 to 156). Overall, 45% of children who had neonatal NEC were neurodevelopmentally impaired. Infants with NEC were significantly more likely than infants of similar age and gestation who did not develop NEC to be neurodevelopmentally impaired (1.6 (1.3 to 2.0), p = 0.0001) including a higher risk of cerebral palsy (1.5 (1.2 to 2.0), p = 0.001), visual (2.3 (1.0 to 5.1), p = 0.04), cognitive (1.7 (1.4 to 2.2), p<0.0001) and psychomotor impairment (1.7 (1.3 to 2.2), p<0.0001). The odds ratio of neurodevelopmental impairment was also 2.3 times higher in neonates with Bell's stage III disease or requiring surgery ((1.5 to 3.6), p = 0.0001).

conclusionsNEC is associated with significantly worse neurodevelopmental outcome than prematurity alone. Presence of advanced NEC and need for surgery increase the risk of neurological impairment.

Indexed as

Infant, Very Low Birth WeightCognition DisordersDevelopmental DisabilitiesEnterocolitis, NecrotizingHumansInfant, NewbornNervous System DiseasesRisk Factors

Identifiers

PMID16984980
PMCPMC2675329
OpenAlexW2172109416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.