ArticleBMC immunology2006
Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid.
Article in BMC immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4Cardiovascular diabetology · 2023Article
- Chemokines and chemokine receptors as promising targets in rheumatoid arthritis.Frontiers in immunology · 2023Review
- The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages.Nature metabolism · 2022Article
- Histamine Increases Th2 Cytokine-Induced CCL18 Expression in Human M2 Macrophages.International journal of molecular sciences · 2021Article
- Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma.Frontiers in cell and developmental biology · 2020Review
- Serum and synovial fluid levels of CCL18 are correlated with radiographic grading of knee osteoarthritis.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- An immunosuppressive subtype of neutrophils identified in patients with hepatocellular carcinoma.Journal of clinical biochemistry and nutrition · 2012Article
- The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum.Immunology · 2012Article
- Azithromycin distinctively modulates classical activation of human monocytes in vitro.British journal of pharmacology · 2012Article
- Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps.The Journal of allergy and clinical immunology · 2012Article
- An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells.Journal of leukocyte biology · 2010Article
- Chemokines and chemokine receptors in arthritis.Frontiers in bioscience (Scholar edition) · 2010Review
- Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype.PloS one · 2008Article
- Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis.Annals of the rheumatic diseases · 2007Article
- Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis.Arthritis research & therapy · 2007Article
- Cells of the synovium in rheumatoid arthritis. Dendritic cells.Arthritis research & therapy · 2007Review
- Developments in the synovial biology field 2006.Arthritis research & therapy · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role for CCL18 has been suggested in the pathogenesis of a variety of diseases. Rheumatoid arthritis (RA) is one of these conditions, in which abundant CCL18 production is present. Although Th2 cytokines and IL-10 are known to have an effect on CCL18 production, there are several gaps in our knowledge regarding the exact regulation of CCL18 secretion, both in general and in RA. In this study we provide new insights in the regulation of CCL18 secretion by monocytes and dendritic cells.
resultsIn contrast to a large panel of pro-inflammatory stimuli (IL-1beta, TNF-alpha, IL-10, IL-13, IL-15, IL-17, IL-18, IFN-gamma), T cell mimicking molecules (RANKL, CD40L) or TLR driven maturation, the anti-inflammatory IL-10 strongly stimulated DC to secrete CCL18. On freshly isolated monocytes, CCL18 secretion was induced by IL-4 and IL-13, in strong synergy with IL-10. This synergistic effect could already be observed after only 24 hours, indicating that not only macrophages and dendritic cells, but also monocytes secrete CCL18 under these stimulatory conditions. A high CCL18 expression was detected in RA synovial tissue and incubation of monocytes with synovial fluid from RA patients clearly enhanced the effects of IL-4, IL-13 and IL-10. Surprisingly, the effect of synovial fluid was not driven by IL-10 of IL-13, suggesting the presence of another CCL18 inducing factor in synovial fluid.
conclusionIn summary, IL-10 synergistically induces CCL18 secretion in combination with IL-4 of IL-13 on monocytes and monocyte derived cells. The effects of IL-14, IL-13 and IL-10 are strongly enhanced by synovial fluid. This synergy may contribute to the high CCL18 expression in RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.