ArticleIntensive care medicine2006
Outcome in bacteremia associated with nosocomial pneumonia and the impact of pathogen prediction by tracheal surveillance cultures.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Reevaluation of the impact of methicillin-resistance on outcomes in patients with Staphylococcus aureus bacteremia and endocarditis.The Korean journal of internal medicine · 2019Pooled it
- Value of lower respiratory tract surveillance cultures to predict bacterial pathogens in ventilator-associated pneumonia: systematic review and diagnostic test accuracy meta-analysis.Intensive care medicine · 2013Pooled it
- Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis.Antimicrobial agents and chemotherapy · 2010Pooled it
- Hospital acquired infections in Intensive Care Unit: A study on incidence, antibiotic resistance profile and outcome of the patients in a tertiary care unit in Eastern India.AIMS microbiology · 2025Article
- Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.Intensive & critical care nursing · 2022Article
- Derivation and validation of a simple score to predict the presence of bacteria requiring carbapenem treatment in ICU-acquired bloodstream infection and pneumonia: CarbaSCORE.Antimicrobial resistance and infection control · 2019Article
- Epidemiology of Multidrug Resistant Infections after Inter-ICU Transfer in India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Clinical manifestations of pneumonia according to the causative organism in patients in the intensive care unit.The Korean journal of internal medicine · 2015Observational
- Potential role for telavancin in bacteremic infections due to gram-positive pathogens: focus on Staphylococcus aureus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Minimizing antibiotic exposure in the ICU: in search of the optimal strategy.Critical care (London, England) · 2014Article
- De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study.Intensive care medicine · 2014Observational
- Outcomes in critically ill chronic lymphocytic leukemia patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Review
- Self-trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro.The FEBS journal · 2013Article
- Assessment of microbial diversity in biofilms recovered from endotracheal tubes using culture dependent and independent approaches.PloS one · 2012Article
- The role of surveillance cultures in the prediction of susceptibility patterns of Gram-negative bacilli in the intensive care unit.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- Predictors of bacteraemia and mortality in patients with acute liver failure.Intensive care medicine · 2009Article
- Maximizing rates of empiric appropriate antibiotic therapy with minimized use of broad-spectrum agents: are surveillance cultures the key?Intensive care medicine · 2008Article
- Screening for resistant gram-negative microorganisms to guide empiric therapy of subsequent infection.Intensive care medicine · 2008Article
- Potent in vitro activity of tomopenem (CS-023) against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether pathogen prediction in bacteremia associated with nosocomial pneumonia (NP) by tracheal surveillance cultures improves adequacy of early antibiotic therapy and impacts mortality. DESIGN AND
settingA retrospective observational study of a prospectively gathered cohort. This cohort included all adult patients admitted to the ICU of a tertiary care hospital from 1992 through 2001 and who developed bacteremia associated with NP. MEASUREMENTS AND MAIN
results128 episodes of bacteremia associated with NP were identified. In 110 episodes a tracheal surveillance culture 48-96h prior to bacteremia was available: this culture predicted the pathogen in 67 episodes (61%). Overall rates of appropriate empiric antibiotic therapy within 24 and 48h were 62 and 87%, respectively. Pathogen prediction was associated with a significantly higher rate of appropriate antibiotic therapy within 24h (71 vs 45%; p=0.01), but not within 48h (91 vs 82%; p=0.15). Crude in-hospital mortality was 50%. Pathogen prediction was associated with increased survival in univariate (OR 0.43; CI 0.19-0.93; p=0.04) and multivariate analysis (OR 0.32; CI 0.12-0.82; p=0.02). Multivariate analysis further identified age (OR 1.04; CI 1.01-1.07; p=0.02), increasing APACHEII score (OR 1.08; CI 1.02-1.15; p=0.01), and methicillin-resistant Staphylococcus aureus (OR 5.90; CI 1.36-25.36; p=0.01) and Pseudomonas aeruginosa (OR 3.30; CI 1.04-10.4; p=0.04) as independent risk factors for mortality.
conclusionPathogen prediction in bacteremia associated with NP by tracheal surveillance cultures is associated with a higher rate of adequate empiric antibiotic therapy within 24[Symbol: see text]h and with increased survival.
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