ArticleOncogene2007
Transcription linked to recombination: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Article
- The KMT2A recombinome of acute leukemias in 2023.Leukemia · 2023Article
- DNA fragility at theOpen biology · 2023Review
- Human topoisomerases and their roles in genome stability and organization.Nature reviews. Molecular cell biology · 2022Review
- NCells · 2020Article
- The MLL recombinome of acute leukemias in 2017.Leukemia · 2018Article
- Article
- Molecular studies revealOncology letters · 2017Article
- MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Frontiers in pediatrics · 2017Review
- Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells.Mutation research · 2015Article
- A role for epigenetics in the formation of chromosome translocations in acute leukemia.Cancer genetics · 2015Review
- Topoisomerase-mediated chromosomal break repair: an emerging player in many games.Nature reviews. Cancer · 2015Review
- Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism.Frontiers in cell and developmental biology · 2015Review
- The MLL recombinome of acute leukemias in 2013.Leukemia · 2013Article
- Gene mutations and molecularly targeted therapies in acute myeloid leukemia.American journal of blood research · 2013Article
- Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL.Mutation research · 2012Article
- Do non-genomically encoded fusion transcripts cause recurrent chromosomal translocations?Cancers · 2012Article
- Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?Cell cycle (Georgetown, Tex.) · 2012Article
- Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MLL gene is frequently involved in chromosomal translocations associated with high-risk acute leukaemia. Infant and therapy-related acute leukaemia patients display chromosomal breakpoints preferentially clustered in the telomeric portion of the MLL breakpoint cluster region (SCII). Here, we demonstrate that SCII colocalizes with a gene-internal promoter element in the mouse and human MLL gene, respectively. The mRNA generated encodes an N-terminally truncated version of MLL that still exhibits many functional regions, including the C-terminal SET-domain. Etoposide-induced DNA double-strand breaks colocalize with the binding site of RNA polymerase II and the transcription initiation region, but not with a nearby Topo II consensus sequence. Thus, the observed genomic instability of the human MLL gene is presumably linked to transcriptional processes. The consequences of this novel finding for the creation of chromosomal translocations, the biology of the MLL protein and for MLL-mediated acute leukaemia are discussed.
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