ArticleProceedings of the National Academy of Sciences of the United States of America2006
Genes with internal repeats require the THO complex for transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Computational tools for tandem repeat detection using long-read sequencing.Briefings in bioinformatics · 2026Review
- A pan-cancer analysis of the oncogenic and immunological roles of THOC3 in human cancer.Scientific reports · 2025Article
- Native functions of short tandem repeats.eLife · 2023Article
- The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions.PLoS biology · 2022Article
- Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes.Nature communications · 2021Article
- Satellite DNA-containing gigantic introns in a unique gene expression program during Drosophila spermatogenesis.PLoS genetics · 2019Article
- Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model.Frontiers in microbiology · 2019Article
- Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved?Biochimica et biophysica acta. Gene regulatory mechanisms · 2017Review
- Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila.Genes & development · 2016Article
- Nuclear pore components affect distinct stages of intron-containing gene expression.Nucleic acids research · 2015Article
- Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs.Nucleic acids research · 2014Article
- The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.PloS one · 2014Article
- Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae.Genetics · 2013Article
- The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase.PloS one · 2013Article
- Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network.Genetics · 2012Article
- Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus.Nucleic acids research · 2012Article
- Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.PLoS genetics · 2011Article
- Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.DNA repair · 2011Article
- Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.The EMBO journal · 2011Article
- Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.RNA (New York, N.Y.) · 2011Article
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6 authors.
Funding
Abstract
The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes, is required for the efficient expression of FLO11 and other yeast genes that have long internal tandem repeats. FLO11 transcription elongation in Tho- mutants is hindered in the region of the tandem repeats, resulting in a loss of function. Moreover, the repeats become genetically unstable in Tho- mutants. A FLO11 gene without the tandem repeats is transcribed equally well in Tho+ or Tho- strains. The Tho- defect in transcription is suppressed by overexpression of topoisomerase I, suggesting that the THO complex functions to rectify aberrant structures that arise during transcription.
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