ArticleJournal of immunology (Baltimore, Md. : 1950)2006
A role for inflammatory mediators in the induction of immunoregulatory B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- [Ultraviolet radiation in the pathogenesis of lupus erythematosus].Dermatologie (Heidelberg, Germany) · 2024Review
- Platelet-activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury.BioFactors (Oxford, England) · 2022Review
- Exposure to solar ultraviolet radiation establishes a novel immune suppressive lipidome in skin-draining lymph nodes.Frontiers in immunology · 2022Article
- Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma.Frontiers in pharmacology · 2022Article
- The role of regulatory B cells in Echinococcus granulosus-infected mice.Parasitology research · 2021Article
- DNA Damage Response and Immune Defense.International journal of molecular sciences · 2020Review
- Lipids in ultraviolet radiation-induced immune modulation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2020Review
- Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2020Review
- Photoimmunology: how ultraviolet radiation affects the immune system.Nature reviews. Immunology · 2019Review
- Skin-Associated B Cells in Health and Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Modulation of the immune response by helminths: a role for serotonin?Bioscience reports · 2018Review
- Boosting Adaptive Immunity: A New Role for PAFR Antagonists.Scientific reports · 2016Article
- Sunlight Effects on Immune System: Is There Something Else in addition to UV-Induced Immunosuppression?BioMed research international · 2016Review
- Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.The Journal of clinical investigation · 2015Article
- A dialogue between the immune system and brain, spoken in the language of serotonin.ACS chemical neuroscience · 2013Review
- The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists.Carcinogenesis · 2012Article
- Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis.Carcinogenesis · 2012Article
- The immunologic revolution: photoimmunology.The Journal of investigative dermatology · 2012Review
- The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation.The American journal of pathology · 2011Article
- Regulatory B cells and allergic diseases.Allergy, asthma & immunology research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
UV exposure suppresses the immune response to a variety of microbial, fungal, and viral Ags. In addition, UV radiation is a complete carcinogen and the immune suppression induced by UV radiation is a major risk factor for skin cancer induction. In this study, we examined the mechanisms underlying the induction of immune suppression and tolerance induction by UV radiation. Transferring lymph nodes cells from UV-irradiated, FITC-sensitized mice into normal recipients transferred immune tolerance. Contrary to expectations, the cell responsible was an FITC(+), IL-10-secreting, CD19(+), B220(+) B cell. Because the lipid mediator of inflammation, platelet-activating factor (PAF) is released by UV-irradiated keratinocytes and is essential for the induction of immune suppression, we determined its role in tolerance induction. When UV-irradiated mice were injected with PCA 4248, a selective PAF receptor (PAFR) antagonist, transfer of tolerance was suppressed. However, immune suppression was not transferred when FITC(+) cells from the draining lymph nodes of UV-irradiated, PAFR-deficient donor mice were injected into the recipients. Because PCA 4248 also blocks serotonin receptor binding, we measured the effect that blocking both serotonin and PAFR binding has on the transfer of immune suppression. Only when both PAF and serotonin binding were blocked could we inhibit tolerance induction. These data identify a novel function for PAF and serotonin in modulating immune function, the activation of immunoregulatory B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.