ArticleInfection and immunity2006
Identification and characterization of a novel ABC iron transport system, fit, in Escherichia coli.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Context-dependent siderophore exploitability shapes microbial community structure.The ISME journal · 2026Article
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- The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance.Archives of microbiology · 2025Review
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- The iron hand of uropathogenic Escherichia coli: the role of transition metal control in virulence.Future microbiology · 2018Review
- Article
- When Genome-Based Approach Meets the "Old but Good": Revealing Genes Involved in the Antibacterial Activity of Pseudomonas sp. P482 against Soft Rot Pathogens.Frontiers in microbiology · 2016Article
- Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition.Drug design, development and therapy · 2015Article
- Combining quantitative genetic footprinting and trait enrichment analysis to identify fitness determinants of a bacterial pathogen.PLoS genetics · 2013Article
- Article
- Redundancy and specificity of Escherichia coli iron acquisition systems during urinary tract infection.Infection and immunity · 2011Article
- Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Sequence analysis and characterization of a transferable hybrid plasmid encoding multidrug resistance and enabling zoonotic potential for extraintestinal Escherichia coli.Infection and immunity · 2010Article
- Transcriptome analysis of Escherichia coli O157:H7 exposed to lysates of lettuce leaves.Applied and environmental microbiology · 2010Article
- A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Escherichia coli O157:H7 survives within human macrophages: global gene expression profile and involvement of the Shiga toxins.Infection and immunity · 2008Article
- Identification of a Novel Regulator for the Escherichia coli fit Iron Transport System.The open microbiology journal · 2008Article
- Defining genomic islands and uropathogen-specific genes in uropathogenic Escherichia coli.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A putative ABC transporter, fit, with significant homology to several bacterial iron transporters was identified in Escherichia coli. The E. coli fit system consists of six genes designated fitA, -B, -C, -D, -E, and -R. Based on DNA sequence analysis, fit encodes an outer membrane protein (FitA), a periplasmic binding protein (FitE), two permease proteins (FitC and -D), an ATPase (FitB), and a hypothetical protein (FitR). Introduction of the E. coli fit system into E. coli strain K-12 increased intracellular iron content and transformed bacteria were more sensitive to streptonigrin, which suggested that fit transports iron in E. coli. Expression of fit was studied using a lacZ reporter assay. A functional, bidirectional promoter was identified in the intergenic region between genes fitA and fitB. The expression of the E. coli fit system was found to be induced by iron limitation and repressed when Fe(2+) was added to minimal medium. Several fit mutants were created in E. coli using an in vitro transposon mutagenesis strategy. Mutations in fit did not affect bacterial growth in iron-restricted media. Using a growth promotion test, it was found that fit was not able to transport enterobactin, ferrichrome, transferrin, and lactoferrin in E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.