ArticleInfection and immunity2006
Rat strains differ in susceptibility to Ureaplasma parvum-induced urinary tract infection and struvite stone formation.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Urolithiasis in a captive Siberian chipmunk (Eutamias sibiricus).The Journal of veterinary medical science · 2021Article
- Fetal growth restriction is a host specific response to infection with an impaired spiral artery remodeling-inducing strain of Porphyromonas gingivalis.Scientific reports · 2020Article
- Urothelial hyperplasia with calculi (papillomatosis) in the urinary bladder of a male spontaneous diabetic Torii rat.Journal of toxicologic pathology · 2020Article
- Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models.GMS infectious diseases · 2020Review
- Struvite Urolithiasis in Long-Evans Rats.Comparative medicine · 2015Article
- Host genetic background impacts disease outcome during intrauterine infection with Ureaplasma parvum.PloS one · 2012Article
- Ureaplasma parvum infection alters filamin A dynamics in host cells.BMC infectious diseases · 2011Article
- Complicated urinary tract infection is associated with uroepithelial expression of proinflammatory protein S100A8.Infection and immunity · 2009Article
- Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation.BMC infectious diseases · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of Ureaplasma parvum. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1alpha (IL-1alpha), and IL-1beta. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.
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