Evidence map›Paper›PMID 16982791›Full record

ArticleAntimicrobial agents and chemotherapy2006

Rapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection.

Jamela Seedat, Günther Zick, Ingo Klare, Carola Konstabel, Norbert Weiler, Hany Sahly

Abstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Review
  3. Resistance ofFrontiers in microbiology · 2018
    Article
  4. [Enterococci and surgical site infections : Causal agent or harmless commensals?]Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017
    Review
  5. Article
  6. Article
  7. Article
  8. Use of linezolid in neonatal and pediatric inpatient facilities--results of a retrospective multicenter survey.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
    Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jamela SeedatInstitute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Brunswiker Str. 4, D-24105 Kiel, Germany.
Günther Zick
Ingo Klare
Carola Konstabel
Norbert Weiler
Hany Sahly
Biology of Infection · FRRobert Koch Institute · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the emergence of linezolid resistance (MICs of 16 to 32 mg/liter) in clonally related vancomycin-susceptible and -resistant Enterococcus faecium isolates from an intensive care unit patient after 12 days of linezolid therapy. Only linezolid-susceptible isolates of the same clone were detected at 28 days after termination of linezolid therapy.

Indexed as

AcetamidesAgedAnti-Bacterial AgentsDrug Resistance, BacterialEnterococcus faeciumFemaleGram-Positive Bacterial InfectionsHumansIntensive Care UnitsLinezolidMicrobial Sensitivity TestsOxazolidinonesTime FactorsTreatment OutcomeAcetamidesAnti-Bacterial AgentsLinezolidOxazolidinones

Identifiers

PMID16982791
PMCPMC1694002
OpenAlexW2103708630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.