ArticleNeuron2006
The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells.
Article in Neuron, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed.
- Natural motion statistics unify direction computations.bioRxiv : the preprint server for biology · 2026Article
- Long-distance object motion evokes direction selectivity in retinal neurons through nicotinic receptors in bipolar cells.Journal of neurophysiology · 2026Article
- PTEN regulates starburst amacrine cell dendrite morphology during development.Development (Cambridge, England) · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Decreased GABA levels during development result in increased connectivity in the larval zebrafish tectum.bioRxiv : the preprint server for biology · 2024Article
- Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells.Nature communications · 2024Article
- Direct comparison reveals algorithmic similarities in fly and mouse visual motion detection.iScience · 2023Article
- Asymmetric connections with starburst amacrine cells underlie the upward motion selectivity of J-type retinal ganglion cells.PLoS biology · 2023Article
- Article
- Two mechanisms for direction selectivity in a model of the primate starburst amacrine cell.Visual neuroscience · 2023Article
- Special nuclear layer contacts between starburst amacrine cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- Presynaptic depolarization differentially regulates dual neurotransmitter release from starburst amacrine cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022Review
- Conserved circuits for direction selectivity in the primate retina.Current biology : CB · 2022Article
- Origins of direction selectivity in the primate retina.Nature communications · 2022Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Patch-clamp recordings revealed that distal processes of starburst amacrine cells (SACs) received largely excitatory synaptic input from the receptive field center and nearly purely inhibitory inputs from the surround during both stationary and moving light stimulations. The direct surround inhibition was mediated mainly by reciprocal GABA(A) synapses between opposing SACs, which provided leading and prolonged inhibition during centripetal stimulus motion. Simultaneous Ca(2+) imaging and current-clamp recording during apparent-motion stimulation further demonstrated the contributions of both centrifugal excitation and GABA(A/C)-receptor-mediated centripetal inhibition to the direction-selective Ca(2+) responses in SAC distal processes. Thus, by placing GABA release sites in electrotonically semi-isolated distal processes and endowing these sites with reciprocal GABA(A) synapses, SACs use a radial-symmetric center-surround receptive field structure to build a polar-asymmetric circuitry. This circuitry may integrate at least three levels of interactions--center excitation, surround inhibition, and reciprocal inhibitions that amplify the center--surround antagonism-to generate robust direction selectivity in the distal processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.