Trial reportNeuroImage2006
Striatal dopamine release during performance of executive functions: A [(11)C] raclopride PET study.
Trial report in NeuroImage, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacological and non-pharmacological modulation of striatal dopamine release: a meta-analysis of [Molecular psychiatry · 2026Pooled it
- The dopaminergic basis of human behaviors: A review of molecular imaging studies.Neuroscience and biobehavioral reviews · 2009Pooled it
- Trial
- miR-218 Regulates the Excitability of VTA Dopamine Neurons and the Mesoaccumbens Pathway in Mice.Brain sciences · 2025Article
- Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.Brain and behavior · 2024Article
- Decision-making under ambiguity and risk and executive functions in Parkinson's disease patients: A scoping review of the studies investigating the Iowa Gambling Task and the Game of Dice.Cognitive, affective & behavioral neuroscience · 2023Article
- Physical inactivity during adolescence heightens risk for cannabis use disorder in adulthood.Experimental and clinical psychopharmacology · 2023Article
- Characteristics of psychological time in patients with depression and potential intervention strategies.Frontiers in psychiatry · 2023Review
- Shared genetic influences on resting-state functional networks of the brain.Human brain mapping · 2022Article
- Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice.Frontiers in neuroscience · 2022Article
- BDNF and its Role in the Alcohol Abuse Initiated During Early Adolescence: Evidence from Preclinical and Clinical Studies.Current neuropharmacology · 2022Review
- A Monte Carlo approach for improving transient dopamine release detection sensitivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging.Frontiers in human neuroscience · 2021Article
- Relationships Between Catecholamine Levels and Stress or Intelligence.Neurochemical research · 2019Article
- Impaired Prefrontal Cortical Dopamine Release in Schizophrenia During a Cognitive Task: A [11C]FLB 457 Positron Emission Tomography Study.Schizophrenia bulletin · 2019Article
- Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Physical Exercise for Individuals with Hypertension: It Is Time to Emphasize its Benefits on the Brain and Cognition.Clinical Medicine Insights. Cardiology · 2019Article
- The Influence of Dopamine on Cognitive Flexibility Is Mediated by Functional Connectivity in Young but Not Older Adults.Journal of cognitive neuroscience · 2018Article
- Functional MRI on executive functioning in aging and dementia: A scoping review of cognitive tasks.Aging medicine (Milton (N.S.W)) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
To date, while the contribution of the striatum in executive processes is well documented, the role played by striatal dopamine during tasks requiring executive functions is still unknown. We used D2-dopamine receptor ligand [(11)C] raclopride PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). We observed a striatal reduction in [(11)C] raclopride binding potential during planning of a set-shift when compared with matching according to an ongoing rule. These findings suggest that striatal dopamine neurotransmission increases significantly during the performance of specific executive processes confirming previous evidence of striatal activation during fMRI studies. The present observation may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.