ArticleMolecular cancer2006
A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer.
Article in Molecular cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- The role of PDGFRA as a therapeutic target in young colorectal cancer patients.Journal of translational medicine · 2021Article
- Integrated analysis of RNA-binding proteins in human colorectal cancer.World journal of surgical oncology · 2020Article
- MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes.Breast cancer research and treatment · 2020Article
- The Role and Therapeutic Potential of miRNAs in Colorectal Liver Metastasis.Scientific reports · 2019Article
- ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway.International journal of oncology · 2019Article
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- MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma.Oxidative medicine and cellular longevity · 2017Article
- Integration of genome scale data for identifying new players in colorectal cancer.World journal of gastroenterology · 2016Review
- Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells.Biomolecules · 2015Article
- Serum microRNA-195 is down-regulated in breast cancer: a potential marker for the diagnosis of breast cancer.Molecular biology reports · 2014Article
- Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Potential Urinary Protein Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients.Journal of Cancer · 2014Article
- miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer.Cell death & disease · 2012Article
- Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer.Medical oncology (Northwood, London, England) · 2012Article
- Comparison of microarray platforms for measuring differential microRNA expression in paired normal/cancer colon tissues.PloS one · 2012Article
- Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers.PloS one · 2012Article
- The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.Molecular cancer research : MCR · 2012Article
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13 authors.
Funding
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Abstract
backgroundCancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression.
resultsWe investigated genome-wide gene expression in colorectal carcinoma (CRC) and normal epithelial tissues from 25 patients using oligonucleotide arrays. This allowed us to identify 81 distinct chromosomal islands with aberrant gene expression. Of these, 38 islands show a gain in expression and 43 a loss of expression. In total, 7.892 genes (25.3% of all human genes) are located in aberrantly expressed islands. Many chromosomal regions that are linked to hereditary colorectal cancer show deregulated expression. Also, many known tumor genes localize to chromosomal islands of misregulated expression in CRC.
conclusionAn extensive comparison with published CGH data suggests that chromosomal regions known for frequent deletions in colon cancer tend to show reduced expression. In contrast, regions that are often amplified in colorectal tumors exhibit heterogeneous expression patterns: even show a decrease of mRNA expression. Because for several islands of deregulated expression chromosomal aberrations have never been observed, we speculate that additional mechanisms (like abnormal states of regional chromatin) also have a substantial impact on the formation of co-expression islands in colorectal carcinoma.
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