ArticleLipids2006
Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy.
Article in Lipids, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- PROTAC Enabling FormulationMolecular pharmaceutics · 2025Article
- How I Manage My Patients with Gall Bladder Cancer?Indian journal of surgical oncology · 2024Review
- Microbiome metabolite quantification methods enabling insights into human health and disease.Methods (San Diego, Calif.) · 2024Review
- Article
- Distinguishing NASH Histological Severity Using a Multiplatform Metabolomics Approach.Metabolites · 2020Article
- Simultaneous Analysis of Twelve Bile Acids by UPLC-MS and Exploration of the Processing Mechanism of Bile Arisaema by Fermentation.Journal of analytical methods in chemistry · 2019Article
- Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids.PloS one · 2016Article
- A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes.Molecules and cells · 2015Review
- Isotope enhanced approaches in metabolomics.Advances in experimental medicine and biology · 2012Review
- Metabolic profiling of bile in cholangiocarcinoma using in vitro magnetic resonance spectroscopy.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2010Article
- Advances in NMR-based biofluid analysis and metabolite profiling.The Analyst · 2010Review
- Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid.Zoological science · 2010Article
- Detection and quantification of D-glucuronic acid in human bile using 1H NMR spectroscopy: relevance to the diagnosis of pancreatic cancer.Magma (New York, N.Y.) · 2009Article
- Bile acids conjugation in human bile is not random: new insights from (1)H-NMR spectroscopy at 800 MHz.Lipids · 2009Article
- Visualization of bile homeostasis using (1)H-NMR spectroscopy as a route for assessing liver cancer.Lipids · 2009Article
- Metabolomics-based methods for early disease diagnostics.Expert review of molecular diagnostics · 2008Review
- NMR-based metabolomics: Where are we now and where are we going?Progress in nuclear magnetic resonance spectroscopyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1H and 13C NMR spectra of intact human bile were assigned using one-dimensional (1H and 13C) and two-dimensional (1H-1H and 1H-13C) experiments. Individual conjugated bile acids--glycocholic acid, glycodeoxycholic acid, glycochenodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, and taurochenodeoxycholic acid--were identified. The bile acids were quantified accurately and individually in a single step by using distinct and characteristic amide signals. Making use of 13C NMR, the study also suggests a way to analyze unconjugated bile acids separately, if present. Chemical shift assignments and rapid single-step analysis of individual conjugated bile acids from intact bile presented herein may have immense utility in the study of bile acid metabolism and deeper understanding of hepatobiliary diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.