ArticleWorld journal of gastroenterology2006
Evaluation of IGL-1 preservation solution using an orthotopic liver transplantation model.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Static Cold Storage and Machine Perfusion: Redefining the Role of Preservation and Perfusate Solutions.International journal of molecular sciences · 2025Review
- Cell therapy in end-stage liver disease: replace and remodel.Stem cell research & therapy · 2023Review
- Review
- The Optimal PEG for Kidney Preservation: A Preclinical Porcine Study.International journal of molecular sciences · 2018Article
- Graft Reconditioning before Liver Transplantation.Visceral medicine · 2016Article
- Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.World journal of gastroenterology · 2015Article
- Polyethylene glycol rinse solution: an effective way to prevent ischemia-reperfusion injury.World journal of gastroenterology · 2014Article
- High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation.The Journal of surgical research · 2013Article
- IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation.Cell death & disease · 2012Article
- How to protect liver graft with nitric oxide.World journal of gastroenterology · 2011Article
- Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution.World journal of gastroenterology · 2010Article
- Porcine alanine transaminase after liver allo-and xenotransplantation.XenotransplantationReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare, in a pig liver transplantation model, the protective effect of UW with that of IGL-1, a high-sodium preservation solution containing polyethylene glycol (PEG) as an oncotic supply.
methodsAll livers were harvested and grafted orthotopically according to standard techniques. The livers were washed out and preserved for 7 h in IGL-1 (n = 6) or in UW solution (n = 7) at 4 degree centigrade. In a sham group (n = 4), the livers underwent a 60-min warm ischemia at 37 degree centigrade. The hepatocellular injury was assessed in organ preservation solution washed out from the graft at the end of ischemic storage (before revascularization), and in serum 2 h after reperfusion and daily for up to 6 d.
resultsLivers preserved in IGL-1 solution released markedly less AST than that preserved in the UW solution before and after revascularization (P < 0.05). Besides, the activity of creatine kinase-BB, a marker of sinusoidal lining cells injury, was higher in the UW group than in the IGL-1 group (P < 0.05). Histological results showed less necrotic regions in livers preserved in IGL-1 solution; however, no difference was observed for inflammation.
conclusionIGL-1 liquid effectively protects parenchymal and non-parenchymal cells against preservation-reperfusion injuries.
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