ReviewWorld journal of gastroenterology2006
Epigenetic effects of ethanol on liver and gastrointestinal injury.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- NLRP3: a new therapeutic target in alcoholic liver disease.Frontiers in immunology · 2023Review
- Neuro-obstetrics: A multidisciplinary approach to care of women with neurologic disease.Handbook of clinical neurology · 2020Review
- Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles.The Journal of pharmacology and experimental therapeutics · 2019Article
- Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.Alcoholism, clinical and experimental research · 2017Article
- Mystic Acetaldehyde: The Never-Ending Story on Alcoholism.Frontiers in behavioral neuroscience · 2017Review
- Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression.Oncotarget · 2016Article
- In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses.Biomolecules · 2015Article
- Alcohol, Aldehydes, Adducts and Airways.Biomolecules · 2015Review
- Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.Hepatology international · 2014Article
- The functional role of microRNAs in alcoholic liver injury.Journal of cellular and molecular medicine · 2014Review
- Environmental alterations of epigenetics prior to the birth.International review of neurobiology · 2014Review
- Binge ethanol-induced HDAC3 down-regulates Cpt1α expression leading to hepatic steatosis and injury.Alcoholism, clinical and experimental research · 2013Article
- Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex.Journal of molecular neuroscience : MN · 2013Article
- Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics.Biochemical Society transactions · 2013Review
- Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.Current pharmaceutical design · 2013Review
- Impact of altered methylation in cytokine signaling and proteasome function in alcohol and viral-mediated diseases.Alcoholism, clinical and experimental research · 2013Review
- Epigenetic effects of ethanol on the liver and gastrointestinal system.Alcohol research : current reviews · 2013Review
- Epigenetic targets for reversing immune defects caused by alcohol exposure.Alcohol research : current reviews · 2013Review
- Alcohol-induced serotonergic modulation: the role of histone deacetylases.Alcohol (Fayetteville, N.Y.) · 2012Article
- Epigenetic regulation of miR-34a expression in alcoholic liver injury.The American journal of pathology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has opened up a new area of interest in ethanol research and is providing novel insight into actions of ethanol at the nucleosomal level in relation to gene expression and patho-physiological consequences. The epigenetic effects are mainly attributable to ethanol metabolic stress (Emess), generated by the oxidative and non-oxidative metabolism of ethanol, and dysregulation of methionine metabolism. Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.