ArticleBone marrow transplantation2006
Retrospective utility of bronchoscopy after hematopoietic stem cell transplant.
Article in Bone marrow transplantation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation.International journal of hematology · 2008Trial
- How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients.Blood · 2024Review
- Article
- Con: Bronchoscopy is essential for pulmonary infections in patients with haematological malignancies.Breathe (Sheffield, England) · 2020Article
- Article
- Clinical Usefulness of Bronchoalveolar Lavage in the Management of Pulmonary Infiltrates in Adults with Hematological Malignancies and Stem Cell Transplantation.Mediterranean journal of hematology and infectious diseases · 2020Article
- The utility of bronchoscopy in immunocompromised patients: a review.Journal of thoracic disease · 2019Review
- An Analysis of the Clinical Benefit of 37 Bronchoalveolar Lavage Procedures in Patients with Hematologic Disease and Pulmonary Complications.Internal medicine (Tokyo, Japan) · 2019Article
- Utility of bronchoalveolar lavage in the management of immunocompromised patients presenting with lung infiltrates.BMC pulmonary medicine · 2019Article
- Role of bronchoalveolar lavage in the management of immunocompromised patients with pulmonary infiltrates.Annals of translational medicine · 2019Review
- Diagnostic Performance and Safety of Bronchoalveolar Lavage in Thrombocytopenic Haematological Patients for Invasive Fungal Infections Diagnosis: A Monocentric, Retrospective Experience.Mediterranean journal of hematology and infectious diseases · 2019Article
- Transbronchial biopsy in the management of pulmonary complications of hematopoietic stem cell transplantation.Bone marrow transplantation · 2018Article
- Early predictors of mortality in children with pulmonary complications after haematopoietic stem cell transplantation.Pediatric transplantation · 2017Observational
- Diagnostic Evaluation of Pulmonary Abnormalities in Patients with Hematologic Malignancies and Hematopoietic Cell Transplantation.Clinics in chest medicine · 2017Review
- Microbiologic yield of bronchoalveolar lavage specimens from stem cell transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2017Article
- Decline in the Use of Surgical Biopsy for Diagnosis of Pulmonary Disease in Hematopoietic Cell Transplantation Recipients in an Era of Improved Diagnostics and Empirical Therapy.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Article
- Shifted focus of bronchoalveolar lavage in patients with suspected thoracic malignancy: an analysis of 224 patients.Journal of thoracic disease · 2016Article
- Diagnostic value of bronchoalveolar lavage in leukemic and bone marrow transplant patients: the impact of antimicrobial therapy.Mediterranean journal of hematology and infectious diseases · 2015Article
- Pulmonary complications in hematopoietic SCT: a prospective study.Bone marrow transplantation · 2014Article
- Infections Caused by Stenotrophomonas maltophilia in Recipients of Hematopoietic Stem Cell Transplantation.Frontiers in oncology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is thought to be the procedure of choice to evaluate pulmonary infiltrates in hematopoietic stem cell transplant (HSCT) recipients. We retrospectively reviewed 91 bronchoscopies performed on 190 in-patient HSCT recipients admitted or treated for pneumonia from January 1994 to December 2004. These yielded a diagnosis 49% of the time with an overall survival of 35 days post-bronchoscopy. We were unable to detect any survival benefit from an addition to the treatment regimen after a positive result from analysis of the BAL fluid or transbronchial biopsy. The most common bacteria isolated was Pseudomonas that was often resistant to the patient's current antibiotics, suggesting that in lieu of this diagnostic procedure, changes to better cover resistant Gram-negative bacteria are reasonable. Although transbronchial biopsies provided an additional diagnosis in one out of 21 biopsies performed, six of the seven complications in our series were directly related to the transbronchial biopsy. With approximately a 50% yield from a bronchoscopy, additional treatment given after only 20% of all bronchoscopies, and no detectable survival benefit with a bronchoscopy that yielded a diagnosis, the utility of a bronchoscopy in this patient population is questioned by these data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.